CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037404
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Kinesin heavy chain isoform 5C 
Protein Synonyms/Alias
  
Gene Name
 KIF5C 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
132TEKKLSGKLYLVDLAubiquitination[1, 2]
146AGSEKVSKTGAEGAVubiquitination[1, 2]
158GAVLDEAKNINKSLSubiquitination[3]
162DEAKNINKSLSALGNubiquitination[1]
751NNLEQLTKVHKQLVRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 862 AA 
Protein Sequence
MWGKLHDPQL MGIIPRIAHD IFDHIYSMDE NLEFHIKVSY FEIYLDKIRD LLDVSKTNLA 60
VHEDKNRVPY VKGCTERFVS SPEEVMDVID EGKANRHVAV TNMNEHSSRS HSIFLINIKQ 120
ENVETEKKLS GKLYLVDLAG SEKVSKTGAE GAVLDEAKNI NKSLSALGNV ISALAEGTKT 180
HVPYRDSKMT RILQDSLGGN CRTTIVICCS PSVFNEAETK STLMFGQRAK TIKNTVSVNL 240
ELTAEEWKKK YEKEKEKNKT LKNVIQHLEM ELNRWRNGEA VPEDEQISAK DQKNLEPCDN 300
TPIIDNIAPV VAGISTEEKE KYDEEISSLY RQLDDKDDEI NQQSQLAEKL KQQMLDQDEL 360
LASTRRDYEK IQEELTRLQI ENEAAKDEVK EVLQALEELA VNYDQKSQEV EDKTRANEQL 420
TDELAQKTTT LTTTQRELSQ LQELSNHQKK RATEILNLLL KDLGEIGGII GTNDVKTLAD 480
VNGVIEEEFT MARLYISKMK SEVKSLVNRS KQLESAQMDS NRKMNASERE LAACQLLISQ 540
HEAKIKSLTD YMQNMEQKRR QLEESQDSLS EELAKLRAQE KMHEVSFQDK EKEHLTRLQD 600
AEEMKKALEQ QMESHREAHQ KQLSRLRDEI EEKQKIIDEI RDLNQKLQLE QEKLSSDYNK 660
LKIEDQEREM KLEKLLLLND KREQAREDLK GLEETVSREL QTLHNLRKLF VQDLTTRVKK 720
SVELDNDDGG GSAAQKQKIS FLENNLEQLT KVHKQLVRDN ADLRCELPKL EKRLRATAER 780
VKALESALKE AKENAMRDRK RYQQEVDRIK EAVRAKNMAR RAHSAQIAKP IRPGHYPASS 840
PTAVHAIRGG GGSSSNSTHY QK 862 
Gene Ontology
 GO:0005875; C:microtubule associated complex; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003777; F:microtubule motor activity; IEA:InterPro.
 GO:0007018; P:microtubule-based movement; IEA:InterPro. 
Interpro
 IPR019821; Kinesin_motor_CS.
 IPR001752; Kinesin_motor_dom.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00225; Kinesin 
SMART
 SM00129; KISc 
PROSITE
 PS00411; KINESIN_MOTOR_DOMAIN1
 PS50067; KINESIN_MOTOR_DOMAIN2 
PRINTS
 PR00380; KINESINHEAVY.