CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031501
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Interferon regulatory factor 7 
Protein Synonyms/Alias
 Interferon regulatory factor 7, isoform CRA_c; cDNA FLJ61529, highly similar to Interferon regulatory factor 7 
Gene Name
 IRF7 
Gene Synonyms/Alias
 hCG_18132 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
10KGRTVLQKVVGHPSCubiquitination[1]
48PAELPDQKQLRYTEEubiquitination[1, 2, 3]
82ARRMGKCKVYWEVGGubiquitination[1, 4]
159EKSLVLVKLEPWLCRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 210 AA 
Protein Sequence
MYKGRTVLQK VVGHPSCTFL YGPPDPAVRA TDPQQVAFPS PAELPDQKQL RYTEELLRHV 60
APGLHLELRG PQLWARRMGK CKVYWEVGGP PGSASPSTPA CLLPRNCDTP IFDFRVFFQE 120
LVEFRARQRR GSPRYTIYLG FGQDLSAGRP KEKSLVLVKL EPWLCRVHLE GTQREGVSSL 180
DSSSLSLCLS SANSLYDDIE CFLMELEQPA 210 
Gene Ontology
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0016064; P:immunoglobulin mediated immune response; IEA:Compara.
 GO:0032607; P:interferon-alpha production; IEA:Compara.
 GO:0032608; P:interferon-beta production; IEA:Compara.
 GO:0060340; P:positive regulation of type I interferon-mediated signaling pathway; IEA:Compara.
 GO:0034124; P:regulation of MyD88-dependent toll-like receptor signaling pathway; IEA:Compara.
 GO:0034127; P:regulation of MyD88-independent toll-like receptor signaling pathway; IEA:Compara.
 GO:0045351; P:type I interferon biosynthetic process; IEA:Compara. 
Interpro
 IPR019471; Interferon_reg_factor-3.
 IPR017855; SMAD_dom-like.
 IPR008984; SMAD_FHA_domain. 
Pfam
 PF10401; IRF-3 
SMART
  
PROSITE
  
PRINTS