UniProt Accession

 DDAH1_HUMAN; O94760; Q5HYC8; Q86XK5 

Genbank Protein ID

 AB001915; BX648145; AC092807; AL078459; AL360219; CH471097; BC033680; BC043235 

Genbank Nucleotide ID

 BAA37117.1; CAI45988.1; EAW73199.1; AAH33680.1; AAH43235.2 

Protein Name

 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 

Protein Synonyms/Alias

 DDAH-1; Dimethylarginine dimethylaminohydrolase 1; DDAHI; Dimethylargininase-1 

Gene Name

 DDAH1 

Gene Synonyms/Alias

 DDAH 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
34	QHALRSAKGEEVDVA	acetylation	[1]

Reference

 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773] 

Functional Description

 Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. 

Sequence Annotation

 REGION 78 79 Substrate binding.
 ACT_SITE 173 173 Proton donor (Probable).
 ACT_SITE 274 274 Nucleophile.
 METAL 274 274 Zinc (By similarity).
 BINDING 30 30 Substrate; via carbonyl oxygen.
 BINDING 73 73 Substrate.
 BINDING 98 98 Substrate.
 BINDING 145 145 Substrate.
 BINDING 268 268 Substrate; via carbonyl oxygen.
 MOD_RES 2 2 N-acetylalanine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Hydrolase; Metal-binding; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 285 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0016597; F:amino acid binding; IEA:Compara.
 GO:0016403; F:dimethylargininase activity; IDA:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006527; P:arginine catabolic process; TAS:ProtInc.
 GO:0000052; P:citrulline metabolic process; IDA:UniProtKB.
 GO:0007263; P:nitric oxide mediated signal transduction; TAS:ProtInc.
 GO:0045766; P:positive regulation of angiogenesis; IEA:Compara.
 GO:0045429; P:positive regulation of nitric oxide biosynthetic process; ISS:BHF-UCL.
 GO:0003073; P:regulation of systemic arterial blood pressure; ISS:BHF-UCL. 

Interpro

 IPR003198; Amidino_trans. 

Pfam

 PF02274; Amidinotransf 

SMART

  

PROSITE

  

PRINTS