| Tag | Content |
|---|
| CPLM ID | CPLM-005151 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transcription initiation factor TFIID subunit 2 |
Protein Synonyms/Alias | TAFII-150; TBP-associated factor 150 kDa; TBP-associated factor 2; TSM-1 |
Gene Name | TAF2 |
Gene Synonyms/Alias | TAF150; TSM1; YCR042C; YCR42C; YCR724 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 120 | QSHFLRSKFASLNEY | ubiquitination | [1] | | 1365 | SLPLRFVKIQQQPRV | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre- initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. |
Sequence Annotation | REGION 1285 1350 Highly charged.
MOD_RES 158 158 Phosphothreonine.
MOD_RES 161 161 Phosphothreonine.
MOD_RES 163 163 Phosphoserine.
MOD_RES 318 318 Phosphoserine. |
Keyword | Coiled coil; Complete proteome; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1407 AA |
Protein Sequence | MMSFSKNATP RAIVSESSTL HEMKFRNFRV AHEKISLDID LATHCITGSA TIIIIPLIQN 60
LEYVTFDCKE MTIKDVLVEN RRCDQFIHDD PLQTNLNGLT SQNVLYSDNS IEQSHFLRSK 120
FASLNEYPET DSKSQLTIKI PSSIKISLED ANALSNYTPI TPSIKTTPGF QESVFTPITL 180
QIEYEIRNPK SGIKFDTVYA DKPWLWNVYT SNGEICSSAS YWVPCVDLLD EKSTWELEFS 240
VPRLVKNIGT SKLIGQNGEE SEKEKEDTPE HDEEEEGKPA RVIKDEDKDS NLKNDEEGKN 300
SKSKDAQDND EEEEEGESDE EEEEGEEERR NIEESNNPSL RDVIVCCSEY SNIKELPHPI 360
DLTKKKCIFQ IINPVAPHHI GWAIGAFNSW SLPLISPPSV DAEDEVEEDK LRENVVDNVN 420
DTMDDDIGSD IIPIQIFTLP TQETDELTVI NSTVVCQKII DFYSKEFGSY PFTCYSMVFL 480
PTAPSKHMDF AALGICNTRL LYPLEVIDKA FSTTNELAWA LANQWSCVNI TPLDMNDYWC 540
CLGIAGYMVF QVTKKLMGNN TYKYQLKRNS EAIVEQDFEK PPIGSTFTGS SRPISWSSKD 600
LSFIQLKAPM ILHILDRRMT KTERSFGMSR VLPKIFLQAM SGDLPNNSLT SSHFQHVCER 660
VNKSKLENFF NEWVYGSGVP ILRVTQRFNR KRMVIELGIR QVQDEELGHE KVVGEEGFFK 720
SALDHLEHPD LNRTECFTGS MTIRIHEHDG TPYEHIVEIK DTFTKIDIQY NTKYRRLRKR 780
GGGANDENGV ENNNEEKPIV VDVNCLGNVY MSPEECSRFS LTEFNRTSES NELLKQNEAF 840
EWIRIDSDLE WICQMHINQP DYMFSSQLRQ DGDIEAQLEA IRYYEDVVVN GGVKSLVYSS 900
ILFRTAIDER YFFGIRLAAC EALSKYVYDP DFTGGVKHLI QIFQILFCLE DSNIPKSNNF 960
ENPKLYFLQC NIPKYLAKVK NENGKCPKLV KQFLLDILVY NENGENKYSD DAYVRSLIEN 1020
VVKVALNEYK DKAYMEKVKT QLLRYENLVN WLSSYESLIK TTIMYAKYKL HKVGAYDFTE 1080
LTGMIMHTLT LGINNGDISR ESFQNEFLMV LKIMLLEGGL KNKDALVLFT EILCFHEDSY 1140
IRDKSVDVLS ECVNLVVMDG SLDTISDDIK SSVQSVHNEV KNIKSEDDIE LFLSGHYVDD 1200
MKIKIEKIGR QNISGLIQIC RDMFKGYSPL KILLWDVLNL PVLSLYQRKQ IHDLVRVMYT 1260
LINSFVVRLE TPRERRLVAK MNSNEEGKLD IVIKRESILK VHIKKEVTST VEAPKKANKI 1320
KISLKGDKPV RKVEKQIVKP KVTSKQRKVK SHVNRMGSLP LRFVKIQQQP RVMVHLSSVP 1380
YSQFVQITKV TSRSFMVKIR TKNDAKN 1407 |
Gene Ontology | GO:0005669; C:transcription factor TFIID complex; IDA:SGD. GO:0003682; F:chromatin binding; IDA:SGD. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0051123; P:RNA polymerase II transcriptional preinitiation complex assembly; IC:SGD. |
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