UniProt Accession

 IRAP_ECOLI; P0AAN9; P21831; P77383; Q2MC43 

Genbank Protein ID

 U73857; U00096; AP009048; M13345; J01659 

Genbank Nucleotide ID

 AAB18106.1; AAC73485.1; BAE76163.1; AAR23118.1 

Protein Name

 Anti-adapter protein IraP 

Protein Synonyms/Alias

  

Gene Name

 iraP 

Gene Synonyms/Alias

 yaiB; b0382; JW0373 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
15	LLFKLAQKEEESKEL	acetylation	[1]
60	EGALYEVKPDASIPD	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway. 

Sequence Annotation

  

Keyword

 Coiled coil; Complete proteome; Cytoplasm; Reference proteome; Stress response. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 86 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0043856; F:anti-sigma factor antagonist activity; IDA:EcoCyc.
 GO:0016036; P:cellular response to phosphate starvation; IMP:EcoCyc.
 GO:0042177; P:negative regulation of protein catabolic process; IDA:EcoCyc. 

Interpro

 IPR019732; SigmaS_Anti-adapt_IraP. 

Pfam

 PF10796; Anti-adapt_IraP 

SMART

  

PROSITE

  

PRINTS