UniProt Accession

 RAB18_MOUSE; P35293; Q543V0 

Genbank Protein ID

 X80333; L04966; AK045514; AK140901; AK143673; AK146177; AK146397; AK154920; BC056351; M79308 

Genbank Nucleotide ID

 CAA56583.1; AAC37632.1; BAC32402.1; BAE24512.1; BAE25489.1; BAE26955.1; BAE27140.1; BAE32926.1; AAH56351.1; AAK14832.1 

Protein Name

 Ras-related protein Rab-18 

Protein Synonyms/Alias

  

Gene Name

 Rab18 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
123	VNMLVGNKIDKENRE	ubiquitination	[1]
126	LVGNKIDKENREVDR	ubiquitination	[1]
138	VDRNEGLKFARKHSM	acetylation	[2, 3]
138	VDRNEGLKFARKHSM	ubiquitination	[1, 4]
183	WESENQNKGVKLSHR	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration (By similarity). 

Sequence Annotation

 NP_BIND 15 23 GTP (By similarity).
 NP_BIND 63 67 GTP (By similarity).
 NP_BIND 122 125 GTP (By similarity).
 NP_BIND 151 153 GTP (By similarity).
 MOTIF 37 45 Effector region (By similarity).
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 203 203 Cysteine methyl ester (Potential).
 LIPID 199 199 S-palmitoyl cysteine (Potential).
 LIPID 203 203 S-geranylgeranyl cysteine (By  

Keyword

 Acetylation; Cell membrane; Complete proteome; Developmental protein; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Palmitate; Prenylation; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 206 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
 GO:0009925; C:basal plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005622; C:intracellular; IEA:Compara.
 GO:0019003; F:GDP binding; ISS:UniProtKB.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0007420; P:brain development; ISS:UniProtKB.
 GO:0001654; P:eye development; ISS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR025662; Sigma_54_int_dom_ATP-bd_1.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 

Pfam

 PF00071; Ras 

SMART

 SM00175; RAB 

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.