UniProt Accession

 C9JXX7_HUMAN; C9JXX7 

Genbank Protein ID

 AC078883 

Genbank Nucleotide ID

  

Protein Name

 Integrin alpha-6 heavy chain 

Protein Synonyms/Alias

  

Gene Name

 ITGA6 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
70	GRLRGHEKFGSCQQG	ubiquitination	[1]
157	SGKGIVSKDEITFVS	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

  

Keyword

 Cell adhesion; Complete proteome; Integrin; Membrane; Receptor; Reference proteome; Transmembrane. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 231 AA 

Protein Sequence

Gene Ontology

 GO:0009925; C:basal plasma membrane; IEA:Compara.
 GO:0005604; C:basement membrane; IEA:Compara.
 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0030056; C:hemidesmosome; IEA:Compara.
 GO:0008305; C:integrin complex; IEA:Compara.
 GO:0050873; P:brown fat cell differentiation; IEA:Compara.
 GO:0033627; P:cell adhesion mediated by integrin; IEA:Compara.
 GO:0007160; P:cell-matrix adhesion; IEA:Compara.
 GO:0031668; P:cellular response to extracellular stimulus; IEA:Compara.
 GO:0046847; P:filopodium assembly; IEA:Compara.
 GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
 GO:0050900; P:leukocyte migration; IEA:Compara.
 GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Compara.
 GO:0022409; P:positive regulation of cell-cell adhesion; IEA:Compara. 

Interpro

 IPR013517; FG-GAP.
 IPR013519; Int_alpha_beta-p.
 IPR000413; Integrin_alpha. 

Pfam

 PF01839; FG-GAP 

SMART

 SM00191; Int_alpha 

PROSITE

 PS51470; FG_GAP 

PRINTS

 PR01185; INTEGRINA.