UniProt Accession

 DHI1_HUMAN; P28845; B2R9Z1; D3DT89 

Genbank Protein ID

 M76665; M76661; M76662; M76663; M76664; AY044084; AY044083; AK313973; AL022398; AL031316; AL031316; AL022398; CH471100; CH471100; BC012593 

Genbank Nucleotide ID

 AAC31757.1; AAC31757.1; AAC31757.1; AAC31757.1; AAC31757.1; AAK83653.1; AAK83653.1; BAG36688.1; CAA18541.2; CAA18541.2; CAI20063.1; CAI20063.1; EAW93445.1; EAW93446.1; AAH12593.1 

Protein Name

 Corticosteroid 11-beta-dehydrogenase isozyme 1 

Protein Synonyms/Alias

 11-beta-hydroxysteroid dehydrogenase 1; 11-DH; 11-beta-HSD1 

Gene Name

 HSD11B1 

Gene Synonyms/Alias

 HSD11; HSD11L 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
56	EMAYHLAKMGAHVVV	methylation	[1]

Reference

 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510] 

Functional Description

 Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol (By similarity). 

Sequence Annotation

 NP_BIND 41 67 NADP.
 NP_BIND 92 93 NADP.
 NP_BIND 119 121 NADP.
 NP_BIND 183 187 NADP.
 NP_BIND 218 222 NADP.
 ACT_SITE 183 183 Proton acceptor.
 BINDING 170 170 Substrate.
 CARBOHYD 123 123 N-linked (GlcNAc...).
 CARBOHYD 162 162 N-linked (GlcNAc...).
 CARBOHYD 207 207 N-linked (GlcNAc...) (Potential).  

Keyword

 3D-structure; Complete proteome; Endoplasmic reticulum; Glycoprotein; Lipid metabolism; Membrane; NADP; Oxidoreductase; Polymorphism; Reference proteome; Signal-anchor; Steroid metabolism; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 292 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0070524; F:11-beta-hydroxysteroid dehydrogenase (NADP+) activity; IEA:EC.
 GO:0003845; F:11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity; TAS:Reactome.
 GO:0006704; P:glucocorticoid biosynthetic process; TAS:Reactome.
 GO:0030324; P:lung development; IEA:Compara.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 

Pfam

 PF00106; adh_short 

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.