CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031901
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 CG3523, isoform C 
Protein Synonyms/Alias
  
Gene Name
 CG3523, Dmel_CG3523 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
813NAEGVFAKAVNSSGYacetylation[1]
840KLRKSLEKIIPNAKNacetylation[1]
926ATNLSLVKRGHENNVacetylation[1]
1062HRATILNKNAVVKFGacetylation[1]
1125LGTNDVYKELRLRGYacetylation[1]
1876FRFMASGKHIGKVVIacetylation[1]
2015LIEDQTAKDFKTVADacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
  
Keyword
 Acyltransferase; Complete proteome; Hydrolase; Lyase; Oxidoreductase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2540 AA 
Protein Sequence
MPLQLNLLQA VDQPHPVAFK PNNCSTHQPQ HSPSTQNNGK SARANRRRRR RRNKQQQNSQ 60
QPDAFRDTDA QLTPSTSSST PHSAPNDRQD HLNSQFNPES INMPARFAEE VITAEPAQRA 120
APQLDLGGGH YVPRQQHLND EIAITGFSGR LPESSTIEEF KQNLFDGVDM VNDDPRRWER 180
GLYGLPDRIG KLKDSDLENF DQQFFGVHQK QAECMDPLLR MLLELTHEAI IDAGLNPSDL 240
RGSRTGVYIG VSNSETEQHW CSDADRVNGY GLTGCARAMF ANRISFTFDF KGPSYSIDTA 300
CSSSLYALEQ AFSDMREGKV DNALVAGAGL ILKPTMSLQF KRLNMLSPDG SCKAFDESGN 360
GYVRSDGCVV LLLQRTSAAR RVYASILNVR TNTDGFKEQG ITYPIGKMQN RLIRETYEEI 420
GLNPADVVYV EAHGTGTKVG DPQEVNSITD FFCKDRTTPL LIGSVKSNMG HSEPASGVCS 480
VAKILIAMEE GVIPGNLHYN KPNPDLYGLV DGRLKVVDRN LPWNGGIIGL NSFGFGGANA 540
HVILKSNPKP KALTPKDGAL KVVLASGRTF EAVEQLLESA STNADDDEYL QLINEIHSKA 600
IPNHFFRGYG VVSSKGTHQR EVIESNDDKR PIWYIYSGMG SQWASMAKDL MKIEAFAKTI 660
QRCADVLKPE GVDLIDVLTR STDKSFENIL NSFISIAAMQ VALTDLLSSL GIHPDGIVGH 720
SVGELGCAYA DGCFTPEQTV LAAYWRGKSI LDTQLAKGKM AAVGLSWEDA HSRVPSDCFP 780
VCHNSEDNCT ISGPEASIEA LVAKLNAEGV FAKAVNSSGY AFHSKYIAEA GPKLRKSLEK 840
IIPNAKNRTA RWISTSIPES AWNTPVAKQS SAAYHVNNLL SPVLFHEALQ HVPKNAISVE 900
IAPHGLLQAI LKRALGPDAT NLSLVKRGHE NNVEFFLTNV GKLFAAGAQP QVLTLVRPIS 960
YPVGRGTPML NSKVGWDHTQ KWLVAKFGKE TSSGETIVEV DLSKEDDAFL AGHTIDGRIL 1020
FPATGYMTLA WQTFAKMQGS EFHKTPVVME NLVFHRATIL NKNAVVKFGI NFFDGTGAFE 1080
ICESGSLAVS GKITIPESID NEELPLEEQT PSAVAKELGT NDVYKELRLR GYDYGGIFRG 1140
IVRSDTVAST GKLQWVDNWI SFMDTMLQFS ILSKNLRELY LPTRIERAVI NPAKHFELLS 1200
ALTKEEQVET GLPVQWYSDI NVIKSAGVEL RGLKANLAQR RPGTQAPPTL ERYQFVPNIN 1260
TTDLNENSEK ARLHALDVAI QVIIENSSGA VKLKGVELAN GRNPDVLVAN RLLQIIEGEP 1320
VLTGDVAVVT SNNNEETITA ALGDSGVRVV SKDVLKEPVE QNCHFVFGID VLSRPDTKTL 1380
ENSIASIREN GFLILEETLP TYTKTGRALL TKFGFVAVQE QSLGATRVLV LARKAVDLKT 1440
RKSVVVVATE QNFNWVDDLK AALATAATEE QYVYVVCQGE ELFGAVGLMT CIKNENGGKL 1500
ARLVFVQDAK AEKFSLTSTL YRQQLEKDLI SNVLKNGAWG TFRHLKLETQ QATLQVEHAY 1560
VNALVKGDLA SLKWIEAAQA DTAATVDKNL ETCTVYYAPI NFRDVMLTSG KLAADALPGD 1620
LAEQDCVLGL EFAGRDTQGR RVMAMVPAKS LATTCVASKR MMWQIPEKWT MEEASTVPCV 1680
YSTVYYALVV RGQMKKGEKI LIHAGSGGVG QAAISVALAH GLTVFTTVGS KEKREFLLKR 1740
FPKLQERNIG NSRDTSFEQL VLRETKGRGV DLVLNSLSEE KLQASIRCLG LNGRFLEIGK 1800
FDLSNNSPLG MSVFLKNTSF HGILLDSVME GEEEMQNQVV SLVAEGIKTG AVVPLPTSVF 1860
NDQQVEQAFR FMASGKHIGK VVIKVRDEEA GKKALQPKPR LINAIPRTYM HPEKSYILVG 1920
GLGGFGLELT NWLVTRGARY IVLTSRSGVK TGYQGLMIRR WQERGVKVVI DTSDVTTAAG 1980
AKKLLENSNK LALVGGIFNL AAVLRDALIE DQTAKDFKTV ADPKVTATKY LDQFSRDICT 2040
ELDYFICFSS VSCGRGNIGQ TNYGLANSAM ERICEQRQVS GFPGTAIQWG AIGDTGLVLE 2100
NLGDNDTVIG GTLPQRMPSC LQTIDLFLQQ PHPVVASMVV AEKRKSDQSA GVSLIATIAN 2160
ILGLRDTKNI QDGASLADLG MDSLMSAEIK QTLERNFDIV LSAQEIRQLT FGALKAMDGG 2220
ADVKPAAAAP AAAAGVPEAN ITSGGSSRTA SPMGDGTQVV FTTSLIPTEA IVQLDTKAPA 2280
NSKQSPIFFI SPIEGFASAL EPLAKRLEVP AYGLQYTEAV PSDSLESAAK FFIKQLRTVQ 2340
PKGPYKLAGY SFGCLLTYVM AGILEETNEV ANVIMLDGAP SYVNWYTSSF KQRYTDGTNA 2400
DNDNQSYGLA YFGIVLANID YKALVRLLIV IPTWEEKLER FAELMSNEIT QPVETIKKSA 2460
TLFYKKLELA DGYQPTLKLK TNVTLVKPTD NSAKLDEDYR LKEVCTKPVE VHTVEGNHRT 2520
FLIEDQSLKT IQSILKRLFN 2540 
Gene Ontology
 GO:0005811; C:lipid particle; IDA:FlyBase.
 GO:0047451; F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; IEA:EC.
 GO:0004317; F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity; IEA:InterPro.
 GO:0004316; F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; IEA:EC.
 GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:EC.
 GO:0004313; F:[acyl-carrier-protein] S-acetyltransferase activity; IEA:EC.
 GO:0004314; F:[acyl-carrier-protein] S-malonyltransferase activity; IEA:EC.
 GO:0004319; F:enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity; IEA:EC.
 GO:0016295; F:myristoyl-[acyl-carrier-protein] hydrolase activity; IEA:EC.
 GO:0004320; F:oleoyl-[acyl-carrier-protein] hydrolase activity; IEA:EC.
 GO:0016296; F:palmitoyl-[acyl-carrier-protein] hydrolase activity; IEA:EC.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0009058; P:biosynthetic process; IEA:InterPro. 
Interpro
 IPR001227; Ac_transferase_dom.
 IPR009081; Acyl_carrier_prot-like.
 IPR014043; Acyl_transferase.
 IPR016035; Acyl_Trfase/lysoPLipase.
 IPR013149; ADH_C.
 IPR023102; Fatty_acid_synthase_dom_2.
 IPR011032; GroES-like.
 IPR018201; Ketoacyl_synth_AS.
 IPR014031; Ketoacyl_synth_C.
 IPR014030; Ketoacyl_synth_N.
 IPR016036; Malonyl_transacylase_ACP-bd.
 IPR016040; NAD(P)-bd_dom.
 IPR020842; PKS/FAS_KR.
 IPR020843; PKS_ER.
 IPR013968; PKS_KR.
 IPR001031; Thioesterase.
 IPR016039; Thiolase-like.
 IPR016038; Thiolase-like_subgr. 
Pfam
 PF00698; Acyl_transf_1
 PF00107; ADH_zinc_N
 PF00109; ketoacyl-synt
 PF02801; Ketoacyl-synt_C
 PF08659; KR
 PF00550; PP-binding
 PF00975; Thioesterase 
SMART
 SM00829; PKS_ER
 SM00822; PKS_KR 
PROSITE
 PS50075; ACP_DOMAIN
 PS00606; B_KETOACYL_SYNTHASE 
PRINTS