CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032301
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 PTPRK protein 
Protein Synonyms/Alias
 Receptor-type tyrosine-protein phosphatase kappa 
Gene Name
 PTPRK 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
227GRDAVHNKLWLQRRNubiquitination[1]
262FRLQEVTKTDQDLYRubiquitination[1]
397MRTPKTLKIAEIQARubiquitination[1]
1197QTNSSHLKDEFQTLNubiquitination[2]
1438VKTLRNSKPNMVEAPubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Protein phosphatase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1462 AA 
Protein Sequence
MDTTAAAALP AFVALLLLSP WPLLGSAQGQ FSAGGCTFDD GPGACDYHQD LYDDFEWVHV 60
SAQEPHYLPP EMPQGSYMIV DSSDHDPGEK ARLQLPTMKE NDTHCIDFSY LLYSQKGLNP 120
GTLNILVRVN KGPLANPIWN VTGFTGRDWL RAELAVSTFW PNEYQVIFEA EVSGGRSGYI 180
AIDDIQVLSY PCDKSPHFLR LGDVEVNAGQ NATFQCIATG RDAVHNKLWL QRRNGEDIPV 240
AQTKNINHRR FAASFRLQEV TKTDQDLYRC VTQSERGSGV SNFAQLIVRE PPRPIAPPQL 300
LGVGPTYLLI QLNANSIIGD GPIILKEVEY RMTSGSWTET HAVNAPTYKL WHLDPDTEYE 360
IRVLLTRPGE GGTGLPGPPL ITRTKCAEPM RTPKTLKIAE IQARRIAVDW ESLGYNITRC 420
HTFNVTICYH YFRGHNESKA DCLDMDPKAP QHVVNHLPPY TNVSLKMILT NPEGRKESEE 480
TIIQTDEDVP GPVPVKSLQG TSFENKIFLN WKEPLDPNGI ITQYEISYSS IRSFDPAVPV 540
AGPPQTVSNL WNSTHHVFMH LHPGTTYQFF IRASTVKGFG PATAINVTTN ISAPTLPDYE 600
GVDASLNETA TTITVLLRPA QAKGAPISAY QIVVEELHPH RTKREAGAME CYQVPVTYQN 660
AMSGGAPYYF AAELPPGNLP EPAPFTVGDN RTYQGFWNPP LAPRKGYNIY FQAMSSVEKE 720
TKTQCVRIAT KAAATEEPEV IPDPAKQTDR VVKIAGISAG ILVFILLLLV VILIVKKSKL 780
AKKRKDAMGN TRQEMTHMVN AMDRSYADQS TLHAEDPLSI TFMDQHNFSP RLPNDPLVPT 840
AVLVPITDEN HSATAESSRL LDVPRYLCEG TESPYQTGQL HPAIRVADLL QHINLMKTSD 900
SYGFKEEYES FFEGQSASWD VAKKDQNRAK NRYGNIIAYD HSRVILQPVE DDPSSDYINA 960
NYIDIWLYRD GYQRPSHYIA TQGPVHETVY DFWRMIWQEQ SACIVMVTNL VEVGRVKCYK 1020
YWPDDTEVYG DFKVTCVEME PLAEYVVRTF TLERRGYNEI REVKQFHFTG WPDHGVPYHA 1080
TGLLSFIRRV KLSNPPSAGP IVVHCSAGAG RTGCYIVIDI MLDMAEREGV VDIYNCVKAL 1140
RSRRINMVQT EEQYIFIHDA ILEACLCGET AIPVCEFKAA YFDMIRIDSQ TNSSHLKDEF 1200
QTLNSVTPRL QAEDCSIACL PRNHDKNRFM DMLPPDRCLP FLITIDGESS NYINAALMDS 1260
YRQPAAFIVT QYPLPNTVKD FWRLVYDYGC TSIVMLNEVD LSQGCPQYWP EEGMLRYGPI 1320
QVECMSCSMD CDVINRIFRI CNLTRPQEGY LMVQQFQYLG WASHREVPGS KRSFLKLILQ 1380
VEKWQEECEE GEGRTIIHCL NGGGRSGMFC AIGIVVEMVK RQNVVDVFHA VKTLRNSKPN 1440
MVEAPEQYRF CYDVALEYLE SS 1462 
Gene Ontology
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
 GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC. 
Interpro
 IPR008985; ConA-like_lec_gl_sf.
 IPR003961; Fibronectin_type3.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR000998; MAM_dom.
 IPR000387; Tyr/Dual-sp_Pase.
 IPR016130; Tyr_Pase_AS.
 IPR000242; Tyr_Pase_rcpt/non-rcpt. 
Pfam
 PF00041; fn3
 PF00629; MAM
 PF00102; Y_phosphatase 
SMART
 SM00060; FN3
 SM00409; IG
 SM00137; MAM
 SM00194; PTPc 
PROSITE
 PS50853; FN3
 PS50835; IG_LIKE
 PS00740; MAM_1
 PS50060; MAM_2
 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50055; TYR_PHOSPHATASE_PTP 
PRINTS
 PR00020; MAMDOMAIN.
 PR00700; PRTYPHPHTASE.