CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018005
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Alstrom syndrome protein 1 
Protein Synonyms/Alias
  
Gene Name
 ALMS1 
Gene Synonyms/Alias
 KIAA0328 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
349LCSYMSWKTRKDTQWubiquitination[1]
896VPGPGDQKTGIPSAPacetylation[2]
896VPGPGDQKTGIPSAPubiquitination[3]
912SFYSHREKPIIFSQQubiquitination[3]
979DLPRESLKMSAIPGLubiquitination[3]
1027YATEKALKVSTGPGPubiquitination[1]
1716SLYSYREKPIVFYQQubiquitination[3]
1839VPGPADQKTGINILPubiquitination[3]
1929VPGQGDRKTEIPTVPubiquitination[3]
2052SSYSQTVKPNILFQQubiquitination[3]
2086LTDVNTGKPVSLSSSubiquitination[3]
2099SSYFHREKSNIFSPQubiquitination[3]
2130IPGPAGQKTVLPTALubiquitination[3]
2146SSFSHREKPDIFYQKubiquitination[3]
2153KPDIFYQKDLPDRHLubiquitination[3]
2256QDAENSAKTLKEIRTubiquitination[3]
2274EAENMALKRCNFPAPubiquitination[1, 3, 4]
2297DISFIQSKKVVCFKEubiquitination[3]
2298ISFIQSKKVVCFKEPubiquitination[3]
2333PSSRCIQKDIGTQTNubiquitination[3]
2342IGTQTNLKCRRGIENubiquitination[3]
2368PLQEAESKVSMALEEubiquitination[3]
2384LRQYQAAKSVMRSEPubiquitination[3]
2401CSGTIGNKIIIPMMTubiquitination[3]
2496ESSLNHAKEILRNAEubiquitination[3]
2538LNEDDRRKVEEIKAEubiquitination[3]
2543RRKVEEIKAELFGHGubiquitination[3]
2557GRTTDLSKGLQSPRGubiquitination[1, 3]
2568SPRGMGCKPEAVCSHubiquitination[3]
2624NPSSCRAKHVNLSASubiquitination[3]
2648VWNSLQLKSHSPFQNubiquitination[3]
2662NFIPDEFKISKGLRMubiquitination[3]
2665PDEFKISKGLRMPFDubiquitination[3]
2674LRMPFDEKMDPWLSEubiquitination[3]
2723FSSHRHSKCISNSSVubiquitination[3]
2782MHSNSQDKEVTILAEubiquitination[3]
2796EGRRQSQKLPVDFERubiquitination[3]
2809ERSFQEEKPLERSDFubiquitination[3]
2833RANCSNFKEIQISDNubiquitination[3]
2867SRLGVKEKNVTITPDubiquitination[3, 4]
2891RELFEQSKAPRADDHubiquitination[3]
2901RADDHVRKHHSPSPQubiquitination[3]
2933RELFEQCKAPYVDHQubiquitination[3]
3057LCPKTSSKLDSGTLDubiquitination[3]
3075HSLDAASKARMNSEFubiquitination[3]
3099RSLEPTSKLLTSKPVubiquitination[3]
3104TSKLLTSKPVAQDQEubiquitination[3]
3185DRLPEKMKTPLSAFSubiquitination[1, 3]
3194PLSAFSEKLSSDAVTubiquitination[3]
3268QPLLLPYKPSGSTKMubiquitination[3]
3274YKPSGSTKMYYVPQLubiquitination[3]
3291IPPSPDSKSDTTVESubiquitination[1]
3429MKNLPDTKAITQKEEubiquitination[3]
3434DTKAITQKEEIHRKKubiquitination[3]
3502ICHESLGKSVFMRHSubiquitination[3]
3511VFMRHSWKDFFQHHPubiquitination[3]
3520FFQHHPDKHREHMCLubiquitination[3]
3536LPYQNMDKTKTDYTRubiquitination[3]
3563KEVMDTTKSQVRDYPubiquitination[3]
3584SDPQRDQKVTPEQTTubiquitination[3]
3603SLNELWNKYRERQRQubiquitination[3]
3884QNVHMLNKGIQAGNLubiquitination[3]
3973NVESRSKKENVPNTCubiquitination[3]
4097NRMCPLPKRVFLAIQubiquitination[3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells. 
Sequence Annotation
 REPEAT 538 584 1.
 REPEAT 585 631 2.
 REPEAT 632 678 3.
 REPEAT 679 725 4.
 REPEAT 726 773 5.
 REPEAT 774 820 6.
 REPEAT 821 870 7.
 REPEAT 871 917 8.
 REPEAT 918 964 9.
 REPEAT 965 1012 10.
 REPEAT 1013 1059 11.
 REPEAT 1060 1106 12.
 REPEAT 1107 1154 13.
 REPEAT 1155 1201 14.
 REPEAT 1202 1248 15.
 REPEAT 1249 1296 16.
 REPEAT 1297 1343 17.
 REPEAT 1344 1391 18.
 REPEAT 1392 1438 19.
 REPEAT 1439 1485 20.
 REPEAT 1486 1533 21.
 REPEAT 1534 1580 22.
 REPEAT 1581 1627 23.
 REPEAT 1628 1674 24.
 REPEAT 1675 1721 25.
 REPEAT 1722 1768 26.
 REPEAT 1769 1815 27.
 REPEAT 1816 1860 28.
 REPEAT 1861 1905 29.
 REPEAT 1906 1950 30.
 REPEAT 1951 1998 31.
 REPEAT 2059 2104 32.
 REPEAT 2105 2151 33.
 REPEAT 2152 2199 34.
 REGION 538 2199 34 X 47 AA approximate tandem repeat.
 REGION 4035 4167 ALMS motif.
 MOD_RES 2631 2631 Phosphoserine.
 MOD_RES 3406 3406 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Cell projection; Ciliopathy; Cilium; Complete proteome; Cone-rod dystrophy; Cytoplasm; Cytoskeleton; Deafness; Diabetes mellitus; Obesity; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4167 AA 
Protein Sequence
MEPEDLPWPG ELEEEEEEEE EEEEEEEEAA AAAAANVDDV VVVEEVEEEA GRELDSDSHY 60
GPQHLESIDD EEDEEAKAWL QAHPGRILPP LSPPQHRYSE GERTSLEKIV PLTCHVWQQI 120
VYQGNSRTQI SDTNVVCLET TAQRGSGDDQ KTESWHCLPQ EMDSSQTLDT SQTRFNVRTE 180
DTEVTDFPSL EEGILTQSEN QVKEPNRDLF CSPLLVIQDS FASPDLPLLT CLTQDQEFAP 240
DSLFHQSELS FAPLRGIPDK SEDTEWSSRP SEVSEALFQA TAEVASDLAS SRFSVSQHPL 300
IGSTAVGSQC PFLPSEQGNN EETISSVDEL KIPKDCDRYD DLCSYMSWKT RKDTQWPENN 360
LADKDQVSVA TSFDITDENI ATKRSDHFDA ARSYGQYWTQ EDSSKQAETY LTKGLQGKVE 420
SDVITLDGLN ENAVVCSERV AELQRKPTRE SEYHSSDLRM LRMSPDTVPK APKHLKAGDT 480
SKGGIAKVTQ SNLKSGITTT PVDSDIGSHL SLSLEDLSQL AVSSLETTTG QHTDTLNQKT 540
LADTHLTEET LKVTAIPEPA DQKTATPTVL SSSHSHRGKP SIFYQQGLPD SHLTEEALKV 600
SAAPGLADQT TGMSTLTSTS YSHREKPGTF YQQELPESNL TEEPLEVSAA PGPVEQKTGI 660
PTVSSTSHSH VEDLLFFYRQ TLPDGHLTDQ ALKVSAVSGP ADQKTGTATV LSTPHSHREK 720
PGIFYQQEFA DSHQTEETLT KVSATPGPAD QKTEIPAVQS SSYSQREKPS ILYPQDLADS 780
HLPEEGLKVS AVAGPADQKT GLPTVPSSAY SHREKLLVFY QQALLDSHLP EEALKVSAVS 840
GPADGKTGTP AVTSTSSASS SLGEKPSAFY QQTLPNSHLT EEALKVSIVP GPGDQKTGIP 900
SAPSSFYSHR EKPIIFSQQT LPDFLFPEEA LKVSAVSVLA AQKTGTPTVS SNSHSHSEKS 960
SVFYQQELPD SDLPRESLKM SAIPGLTDQK TVPTPTVPSG SFSHREKPSI FYQQEWPDSY 1020
ATEKALKVST GPGPADQKTE IPAVQSSSYP QREKPSVLYP QVLSDSHLPE ESLKVSAFPG 1080
PADQMTDTPA VPSTFYSQRE KPGIFYQQTL PESHLPKEAL KISVAPGLAD QKTGTPTVTS 1140
TSYSQHREKP SIFHQQALPG THIPEEAQKV SAVTGPGNQK TWIPRVLSTF YSQREKPGIF 1200
YQQTLPGSHI PEEAQKVSPV LGPADQKTGT PTPTSASYSH TEKPGIFYQQ VLPDNHPTEE 1260
ALKISVASEP VDQTTGTPAV TSTSYSQYRE KPSIFYQQSL PSSHLTEEAK NVSAVPGPAD 1320
QKTVIPILPS TFYSHTEKPG VFYQQVLPHS HPTEEALKIS VASEPVDQTT GTPTVTSTSY 1380
SQHTEKPSIF YQQSLPGSHL TEEAKNVSAV PGPGDRKTGI PTLPSTFYSH TEKPGSFYQQ 1440
VLPHSHLPEE ALEVSVAPGP VDQTIGTPTV TSPSSSFGEK PIVIYKQAFP EGHLPEESLK 1500
VSVAPGPVGQ TTGAPTITSP SYSQHRAKSG SFYQLALLGS QIPEEALRVS SAPGPADQTT 1560
GIPTITSTSY SFGEKPIVNY KQAFPDGHLP EEALKVSIVS GPTEKKTDIP AGPLGSSALG 1620
EKPITFYRQA LLDSPLNKEV VKVSAAPGPA DQKTETLPVH STSYSNRGKP VIFYQQTLSD 1680
SHLPEEALKV PPVPGPDAQK TETPSVSSSL YSYREKPIVF YQQALPDSEL TQEALKVSAV 1740
PQPADQKTGL STVTSSFYSH TEKPNISYQQ ELPDSHLTEE ALKVSNVPGP ADQKTGVSTV 1800
TSTSYSHREK PIVSYQRELP HFTEAGLKIL RVPGPADQKT GINILPSNSY PQREHSVISY 1860
EQELPDLTEV TLKAIGVPGP ADQKTGIQIA SSSSYSNREK ASIFHQQELP DVTEEALNVF 1920
VVPGQGDRKT EIPTVPLSYY SRREKPSVIS QQELPDSHLT EEALKVSPVS IPAEQKTGIP 1980
IGLSSSYSHS HKEKLKISTV HIPDDQKTEF PAATLSSYSQ IEKPKISTVI GPNDQKTPSQ 2040
TAFHSSYSQT VKPNILFQQQ LPDRDQSKGI LKISAVPELT DVNTGKPVSL SSSYFHREKS 2100
NIFSPQELPG SHVTEDVLKV STIPGPAGQK TVLPTALPSS FSHREKPDIF YQKDLPDRHL 2160
TEDALKISSA LGQADQITGL QTVPSGTYSH GENHKLVSEH VQRLIDNLNS SDSSVSSNNV 2220
LLNSQADDRV VINKPESAGF RDVGSEEIQD AENSAKTLKE IRTLLMEAEN MALKRCNFPA 2280
PLARFRDISD ISFIQSKKVV CFKEPSSTGV SNGDLLHRQP FTEESPSSRC IQKDIGTQTN 2340
LKCRRGIENW EFISSTTVRS PLQEAESKVS MALEETLRQY QAAKSVMRSE PEGCSGTIGN 2400
KIIIPMMTVI KSDSSSDASD GNGSCSWDSN LPESLESVSD VLLNFFPYVS PKTSITDSRE 2460
EEGVSESEDG GGSSVDSLAA HVKNLLQCES SLNHAKEILR NAEEEESRVR AHAWNMKFNL 2520
AHDCGYSISE LNEDDRRKVE EIKAELFGHG RTTDLSKGLQ SPRGMGCKPE AVCSHIIIES 2580
HEKGCFRTLT SEHPQLDRHP CAFRSAGPSE MTRGRQNPSS CRAKHVNLSA SLDQNNSHFK 2640
VWNSLQLKSH SPFQNFIPDE FKISKGLRMP FDEKMDPWLS ELVEPAFVPP KEVDFHSSSQ 2700
MPSPEPMKKF TTSITFSSHR HSKCISNSSV VKVGVTEGSQ CTGASVGVFN SHFTEEQNPP 2760
RDLKQKTSSP SSFKMHSNSQ DKEVTILAEG RRQSQKLPVD FERSFQEEKP LERSDFTGSH 2820
SEPSTRANCS NFKEIQISDN HTLISMGRPS STLGVNRSSS RLGVKEKNVT ITPDLPSCIF 2880
LEQRELFEQS KAPRADDHVR KHHSPSPQHQ DYVAPDLPSC IFLEQRELFE QCKAPYVDHQ 2940
MRENHSPLPQ GQDSIASDLP SPISLEQCQS KAPGVDDQMN KHHFPLPQGQ DCVVEKNNQH 3000
KPKSHISNIN VEAKFNTVVS QSAPNHCTLA ASASTPPSNR KALSCVHITL CPKTSSKLDS 3060
GTLDERFHSL DAASKARMNS EFNFDLHTVS SRSLEPTSKL LTSKPVAQDQ ESLGFLGPKS 3120
SLDFQVVQPS LPDSNTITQD LKTIPSQNSQ IVTSRQIQVN ISDFEGHSNP EGTPVFADRL 3180
PEKMKTPLSA FSEKLSSDAV TQITTESPEK TLFSSEIFIN AEDRGHEIIE PGNQKLRKAP 3240
VKFASSSSVQ QVTFSRGTDG QPLLLPYKPS GSTKMYYVPQ LRQIPPSPDS KSDTTVESSH 3300
SGSNDAIAPD FPAQVLGTRD DDLSATVNIK HKEGIYSKRV VTKASLPVGE KPLQNENADA 3360
SVQVLITGDE NLSDKKQQEI HSTRAVTEAA QAKEKESLQK DTADSSAAAA AEHSAQVGDP 3420
EMKNLPDTKA ITQKEEIHRK KTVPEEAWPN NKESLQINIE ESECHSEFEN TTRSVFRSAK 3480
FYIHHPVHLP SDQDICHESL GKSVFMRHSW KDFFQHHPDK HREHMCLPLP YQNMDKTKTD 3540
YTRIKSLSIN VNLGNKEVMD TTKSQVRDYP KHNGQISDPQ RDQKVTPEQT TQHTVSLNEL 3600
WNKYRERQRQ QRQPELGDRK ELSLVDRLDR LAKILQNPIT HSLQVSESTH DDSRGERSVK 3660
EWSGRQQQRN KLQKKKRFKS LEKSHKNTGE LKKSKVLSHH RAGRSNQIKI EQIKFDKYIL 3720
SKQPGFNYIS NTSSDCRPSE ESELLTDTTT NILSGTTSTV ESDILTQTDR EVALHERSSS 3780
VSTIDTARLI QAFGHERVCL SPRRIKLYSS ITNQQRRYLE KRSKHSKKVL NTGHPLVTSE 3840
HTRRRHIQVA NHVISSDSIS SSASSFLSSN STFCNKQNVH MLNKGIQAGN LEIVNGAKKH 3900
TRDVGITFPT PSSSEAKLEE NSDVTSWSEE KREEKMLFTG YPEDRKLKKN KKNSHEGVSW 3960
FVPVENVESR SKKENVPNTC GPGISWFEPI TKTRPWREPL REQNCQGQHL DGRGYLAGPG 4020
REAGRDLLRP FVRATLQESL QFHRPDFISR SGERIKRLKL IVQERKLQSM LQTERDALFN 4080
IDRERQGHQN RMCPLPKRVF LAIQKNKPIS KKEMIQRSKR IYEQLPEVQK KREEEKRKSE 4140
YKSYRLRAQL YKKRVTNQLL GRKVPWD 4167 
Gene Ontology
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005929; C:cilium; IEA:UniProtKB-KW.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005932; C:microtubule basal body; IEA:UniProtKB-SubCell.
 GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
 GO:0006915; P:apoptotic process; IEA:Compara.
 GO:0019722; P:calcium-mediated signaling; IEA:Compara.
 GO:0042632; P:cholesterol homeostasis; IEA:Compara.
 GO:0042384; P:cilium assembly; IEA:Compara.
 GO:0048589; P:developmental growth; IEA:Compara.
 GO:0016197; P:endosomal transport; IMP:MGI.
 GO:0050673; P:epithelial cell proliferation; IEA:Compara.
 GO:0001736; P:establishment of planar polarity; IEA:Compara.
 GO:0045444; P:fat cell differentiation; IEA:Compara.
 GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.
 GO:0042593; P:glucose homeostasis; IEA:Compara.
 GO:0060122; P:inner ear receptor stereocilium organization; IEA:Compara.
 GO:0040015; P:negative regulation of multicellular organism growth; IEA:Compara.
 GO:0030728; P:ovulation; IEA:Compara.
 GO:0045598; P:regulation of fat cell differentiation; IEA:Compara.
 GO:0051492; P:regulation of stress fiber assembly; IMP:MGI.
 GO:0046548; P:retinal rod cell development; IEA:Compara.
 GO:0007605; P:sensory perception of sound; IEA:Compara.
 GO:0007286; P:spermatid development; IEA:Compara.
 GO:0006641; P:triglyceride metabolic process; IEA:Compara. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS