Tag | Content |
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CPLM ID | CPLM-014064 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Astrocytic phosphoprotein PEA-15 |
Protein Synonyms/Alias | 15 kDa phosphoprotein enriched in astrocytes |
Gene Name | Pea15 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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98 | EEDELDTKLTRIPSA | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface (By similarity). |
Sequence Annotation | DOMAIN 3 81 DED. REGION 98 107 Microtubule-binding (Potential). REGION 122 129 Microtubule-binding (Potential). MOD_RES 61 61 Phosphoserine (By similarity). MOD_RES 104 104 Phosphoserine; by PKC (By similarity). MOD_RES 116 116 Phosphoserine; alternate. MOD_RES 116 116 Phosphoserine; by CaMK2; alternate (By |
Keyword | Apoptosis; Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Reference proteome; Sugar transport; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 130 AA |
Protein Sequence | MAEYGTLLQD LTNNITLEDL EQLKSACKED IPSEKSEEIT TGSAWFSFLE SHNKLDKDNL 60 SYIEHIFEIS RRPDLLTMVV DYRTRVLKIS EEDELDTKLT RIPSAKKYKD IIRQPSEEEI 120 IKLAPPPKKA 130 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW. GO:0043066; P:negative regulation of apoptotic process; IEA:Compara. GO:0046325; P:negative regulation of glucose import; IEA:Compara. GO:0043278; P:response to morphine; IEP:RGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |