UniProt Accession

 YRDC_HUMAN; Q86U90; Q4W4X8; Q6NVW3; Q7L4E4; Q7Z2I4; Q9H5F8 

Genbank Protein ID

 AY172561; AL929472; CH471059; BC008984; BC067857; BC068057; BC080186; AY286019; AY286020; AF250397; AK027129 

Genbank Nucleotide ID

 AAO41711.1; CAH70083.1; EAX07317.1; AAH08984.3; AAH67857.2; AAH68057.1; AAH80186.2; AAP37053.1; AAP37054.1; AAQ14263.1; BAB15668.1 

Protein Name

 YrdC domain-containing protein, mitochondrial 

Protein Synonyms/Alias

 Dopamine receptor-interacting protein 3; Ischemia/reperfusion-inducible protein homolog; hIRIP 

Gene Name

 YRDC 

Gene Synonyms/Alias

 DRIP3; IRIP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
116	LKGRSEAKPLAVCLG	ubiquitination	[1, 2]
161	ERSEELNKDLNPFTP	ubiquitination	[1, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 May regulate the activity of some transporters (By similarity). 

Sequence Annotation

 DOMAIN 67 257 YrdC-like.
 MOD_RES 60 60 Phosphoserine.  

Keyword

 Complete proteome; Membrane; Mitochondrion; Phosphoprotein; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 279 AA 

Protein Sequence

Gene Ontology

 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0003725; F:double-stranded RNA binding; IEA:InterPro.
 GO:0051051; P:negative regulation of transport; IDA:MGI. 

Interpro

 IPR017945; DHBP_synth_RibB-like_a/b_dom.
 IPR006070; YrdC-like_dom. 

Pfam

 PF01300; Sua5_yciO_yrdC 

SMART

  

PROSITE

 PS51163; YRDC 

PRINTS