CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016251
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein FAM134C 
Protein Synonyms/Alias
  
Gene Name
 FAM134C 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
115NKIWPEIKVPRPDALubiquitination[1, 2]
220DRAYVRLKPALQRLDubiquitination[3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 10 10 Phosphothreonine.
 MOD_RES 26 26 Phosphoserine.
 MOD_RES 258 258 Phosphoserine.
 MOD_RES 260 260 Phosphoserine.
 MOD_RES 283 283 Phosphothreonine.
 MOD_RES 285 285 Phosphoserine.
 MOD_RES 307 307 Phosphothreonine.
 MOD_RES 310 310 Phosphothreonine.
 MOD_RES 313 313 Phosphoserine.
 MOD_RES 320 320 Phosphoserine.
 MOD_RES 360 360 Phosphoserine.
 MOD_RES 440 440 Phosphothreonine.  
Keyword
 Acetylation; Complete proteome; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 466 AA 
Protein Sequence
MAEAEGVPTT PGPASGSTFR GRRDVSGSWE RDQQVEAAQR ALVEVLGPYE PLLSRVQAAL 60
VWERPARSAL WCLGLNAAFW FFALTSLRLV FLLAFGLMII VCIDQWKNKI WPEIKVPRPD 120
ALDNESWGFV HPRLLSVPEL CHHVAEVWVS GTIFIRNVLL FKKQNPGKFC LLSCGILTFL 180
AVLGRYVPGL LLSYLMLVTV MMWPLAVYHR LWDRAYVRLK PALQRLDFSV RGYMMSKQRE 240
RQLRRRALHP ERAMDNHSDS EEELAAFCPQ LDDSTVAREL AITDSEHSDA EVSCTDNGTF 300
NLSRGQTPLT EGSEDLDGHS DPEESFARDL PDFPSINMDP AGLDDEDDTS IGMPSLMYRS 360
PPGAEEPQAP PASRDEAALP ELLLGALPVG SNLTSNLASL VSQGMIQLAL SGASQPGPSG 420
APAQRATRGF LRSPSSDLDT DAEGDDFELL DQSELSQLDP ASSRSH 466 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS