UniProt Accession

 TOM70_MOUSE; Q9CZW5; Q8BNI6 

Genbank Protein ID

 AK012084; AK083586; AK145458; AK150429; BC057096; BC139420; BC139421 

Genbank Nucleotide ID

 BAB28018.1; BAC38960.1; BAE26448.1; BAE29552.1; AAH57096.1; AAI39421.1; AAI39422.1 

Protein Name

 Mitochondrial import receptor subunit TOM70 

Protein Synonyms/Alias

 Mitochondrial precursor proteins import receptor; Translocase of outer membrane 70 kDa subunit 

Gene Name

 Tomm70a 

Gene Synonyms/Alias

 D16Wsu109e 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
171	AAFEQLQKWKEVAQD	ubiquitination	[1]
188	KAVELNPKYVKALFR	acetylation	[2, 3]
188	KAVELNPKYVKALFR	ubiquitination	[1]
248	ENAKEKYKNREPLMP	ubiquitination	[1]
278	IISQPMLKGEKSDED	ubiquitination	[1]
296	EGEALEVKENSGYLK	ubiquitination	[1]
305	NSGYLKAKQYMEEEN	ubiquitination	[1]
315	MEEENYDKIISECSK	acetylation	[3]
362	LDKVISLKEANVKLR	ubiquitination	[1]
436	ACIRLRPKFALAQAQ	acetylation	[3]
436	ACIRLRPKFALAQAQ	ubiquitination	[1]
466	SQVQAAMKGFEEIIK	ubiquitination	[1]
519	NATTYVHKGLLQLQW	acetylation	[3]
532	QWKQDLDKGLELISK	ubiquitination	[1]
566	VQRGNMEKAIDMFNK	ubiquitination	[1]
573	KAIDMFNKAINLAKS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

 Receptor that accelerates the import of all mitochondrial precursor proteins (By similarity). 

Sequence Annotation

 REPEAT 117 150 TPR 1.
 REPEAT 156 189 TPR 2.
 REPEAT 297 330 TPR 3.
 REPEAT 332 365 TPR 4.
 REPEAT 370 403 TPR 5.
 REPEAT 404 437 TPR 6.
 REPEAT 445 478 TPR 7.
 REPEAT 479 512 TPR 8.
 REPEAT 514 547 TPR 9.
 REPEAT 548 581 TPR 10.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 88 88 Phosphothreonine.
 MOD_RES 94 94 Phosphoserine.
 MOD_RES 188 188 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Membrane; Mitochondrion; Mitochondrion outer membrane; Phosphoprotein; Reference proteome; Repeat; TPR repeat; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 611 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:MGI. 

Interpro

 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 

Pfam

 PF13174; TPR_6
 PF13181; TPR_8 

SMART

 SM00028; TPR 

PROSITE

 PS50005; TPR
 PS50293; TPR_REGION 

PRINTS