CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019518
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Discoidin, CUB and LCCL domain-containing protein 2 
Protein Synonyms/Alias
 CUB, LCCL and coagulation factor V/VIII-homology domains protein 1; Endothelial and smooth muscle cell-derived neuropilin-like protein 
Gene Name
 DCBLD2 
Gene Synonyms/Alias
 CLCP1; ESDN 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
391LYSDDGQKWTVYREPubiquitination[1]
410DKIFQGNKDYHQDVRubiquitination[1]
439NPTQWQQKIAMKMELubiquitination[1]
473PRNSNDLKNTTAPPKubiquitination[1]
560HWRNRKKKTEGTYDLubiquitination[1]
594EGWWKGMKQFLPAKAubiquitination[1, 2]
600MKQFLPAKAVDHEETubiquitination[1, 2, 3]
753YDTPKAGKPGLPAPDubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
 DOMAIN 72 186 CUB.
 DOMAIN 187 285 LCCL.
 DOMAIN 292 449 F5/8 type C.
 MOD_RES 606 606 Phosphoserine.
 CARBOHYD 95 95 N-linked (GlcNAc...) (Potential).
 CARBOHYD 155 155 N-linked (GlcNAc...) (Potential).
 CARBOHYD 272 272 N-linked (GlcNAc...) (Potential).
 CARBOHYD 474 474 N-linked (GlcNAc...) (Potential).
 CARBOHYD 516 516 N-linked (GlcNAc...) (Potential).
 CARBOHYD 522 522 N-linked (GlcNAc...) (Potential).
 DISULFID 72 99 By similarity.
 DISULFID 126 148 By similarity.
 DISULFID 215 237 By similarity.
 DISULFID 292 449 By similarity.  
Keyword
 Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 775 AA 
Protein Sequence
MASRAVVRAR RCPQCPQVRA AAAAPAWAAL PLSRSLPPCS NSSSFSMPLF LLLLLVLLLL 60
LEDAGAQQGD GCGHTVLGPE SGTLTSINYP QTYPNSTVCE WEIRVKMGER VRIKFGDFDI 120
EDSDSCHFNY LRIYNGIGVS RTEIGKYCGL GLQMNHSIES KGNEITLLFM SGIHVSGRGF 180
LASYSVIDKQ DLITCLDTAS NFLEPEFSKY CPAGCLLPFA EISGTIPHGY RDSSPLCMAG 240
VHAGVVSNTL GGQISVVISK GIPYYESSLA NNVTSVVGHL STSLFTFKTS GCYGTLGMES 300
GVIADPQITA SSVLEWTDHT GQENSWKPKK ARLKKPGPPW AAFATDEYQW LQIDLNKEKK 360
ITGIITTGST MVEHNYYVSA YRILYSDDGQ KWTVYREPGV EQDKIFQGNK DYHQDVRNNF 420
LPPIIARFIR VNPTQWQQKI AMKMELLGCQ FIPKGRPPKL TQPPPPRNSN DLKNTTAPPK 480
IAKGRAPKFT QPLQPRSSNE FPAQTEQTTA SPDIRNTTVT PNVTKDVALA AVLVPVLVMV 540
LTTLILILVC AWHWRNRKKK TEGTYDLPYW DRAGFYLMVS LACRHNEGWW KGMKQFLPAK 600
AVDHEETPVR YSSSEVNHLS PREVTTVLQA DSAEYAQPLV GGIVGTLHQR STFKPEEGKE 660
AGYADLDPYN SPGQEVYHAY AEPLPITGPE YATPIIMDMS GHPTTSVGQP STSTFKATGN 720
QPPPLVGTYN TLLSRTDSCS SAQAQYDTPK AGKPGLPAPD ELVYQVPQST QEVSGAGRDG 780
ECDVFKEIL 789 
Gene Ontology
 GO:0009986; C:cell surface; IDA:UniProtKB.
 GO:0005887; C:integral to plasma membrane; IDA:UniProtKB.
 GO:0007155; P:cell adhesion; IEA:InterPro.
 GO:0030522; P:intracellular receptor signaling pathway; NAS:UniProtKB.
 GO:0030308; P:negative regulation of cell growth; IDA:UniProtKB.
 GO:0042060; P:wound healing; IDA:UniProtKB. 
Interpro
 IPR000421; Coagulation_fac_5/8-C_type_dom.
 IPR000859; CUB_dom.
 IPR008979; Galactose-bd-like.
 IPR004043; LCCL. 
Pfam
 PF00431; CUB
 PF00754; F5_F8_type_C
 PF03815; LCCL 
SMART
 SM00042; CUB
 SM00231; FA58C
 SM00603; LCCL 
PROSITE
 PS01180; CUB
 PS01285; FA58C_1
 PS01286; FA58C_2
 PS50022; FA58C_3
 PS50820; LCCL 
PRINTS