UniProt Accession

 BACH_HUMAN; O00154; A8K0K7; A8K232; A8K6B8; A8K837; B3KQ12; O43703; Q53Y78; Q5JYL2; Q5JYL3; Q5JYL4; Q5JYL5; Q5JYL6; Q5TGR4; Q9UJM9; Q9Y539; Q9Y540 

Genbank Protein ID

 D88894; AB074415; AB074416; AB074417; AB074418; AB074419; U91316; BT006888; AK289572; AK290097; AK291583; AK292202; AK057168; AL031847; AL031848; AL031847; AL031848; AL031847; AL031848; AL031847; AL031848; AL031848; AL031847; AL031848; AL031847; AL031848; AL031847; AL031848; AL031847; CH471130; CH471130; CH471130; BC017365 

Genbank Nucleotide ID

 BAA24350.1; BAC20174.1; BAC20175.1; BAC20176.1; BAC20177.1; BAC20178.1; AAB61211.1; AAP35534.1; BAF82261.1; BAF82786.1; BAF84272.1; BAF84891.1; BAG51874.1; CAI19440.1; CAI19440.1; CAI19435.1; CAI19435.1; CAI19442.1; CAI19442.1; CAI19443.1; CAI19443.1; CAI19774.1; CAI19774.1; CAI19777.1; CAI19777.1; CAI19778.1; CAI19778.1; CAI19779.1; CAI19779.1; EAW71528.1; EAW71529.1; EAW71530.1; AAH17365.2 

Protein Name

 Cytosolic acyl coenzyme A thioester hydrolase 

Protein Synonyms/Alias

 Acyl-CoA thioesterase 7; Brain acyl-CoA hydrolase; BACH; CTE-IIa; CTE-II; Long chain acyl-CoA thioester hydrolase 

Gene Name

 ACOT7 

Gene Synonyms/Alias

 BACH 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
126	WYVPLSLKNVDKVLE	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May play an important physiological function in brain. May play a regulatory role by modulating the cellular levels of fatty acyl- CoA ligands for certain transcription factors as well as the substrates for fatty acid metabolizing enzymes, contributing to lipid homeostasis. Has broad specificity, active towards fatty acyl-CoAs with chain-lengths of C8-C18. Has a maximal activity toward palmitoyl-CoA. 

Sequence Annotation

 DOMAIN 56 151 Acyl coenzyme A hydrolase 1.
 DOMAIN 242 319 Acyl coenzyme A hydrolase 2.
 ACT_SITE 66 66 By similarity.
 ACT_SITE 255 255 By similarity.
 MOD_RES 168 168 N6-acetyllysine.
 MOD_RES 198 198 N6-acetyllysine.
 MOD_RES 283 283 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Mitochondrion; Reference proteome; Repeat; Serine esterase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 380 AA 

Protein Sequence

Gene Ontology

 GO:0044297; C:cell body; IEA:Compara.
 GO:0005737; C:cytoplasm; TAS:ProtInc.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0004091; F:carboxylesterase activity; IEA:UniProtKB-KW.
 GO:0003824; F:catalytic activity; TAS:ProtInc.
 GO:0000062; F:fatty-acyl-CoA binding; TAS:ProtInc.
 GO:0016290; F:palmitoyl-CoA hydrolase activity; IEA:EC.
 GO:0009062; P:fatty acid catabolic process; IEA:Compara.
 GO:0006629; P:lipid metabolic process; TAS:ProtInc. 

Interpro

 IPR006683; Thioestr_supf. 

Pfam

 PF03061; 4HBT 

SMART

  

PROSITE

  

PRINTS