UniProt Accession

 ARNC_SALTY; O52324; Q8ZNF2 

Genbank Protein ID

 AF036677; AE006468 

Genbank Nucleotide ID

 AAC04771.1; AAL21199.1 

Protein Name

 Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase 

Protein Synonyms/Alias

 Polymyxin resistance protein PmrF; Undecaprenyl-phosphate Ara4FN transferase; Ara4FN transferase 

Gene Name

 arnC 

Gene Synonyms/Alias

 pbgP2; pmrF; STM2298 

Created Date

 July 27, 2013 

Organism

 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 

NCBI Taxa ID

 99287 

Lysine Modification

Position	Peptide	Type	References
116	EIPRLVAKADEGFDV	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Catalyzes the transfer of 4-deoxy-4-formamido-L- arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. Plays an important role in pathogenesis by providing resistance to antimicrobial peptides within macrophages or at other anatomic sites encountered during infection. 

Sequence Annotation

  

Keyword

 Antibiotic resistance; Cell inner membrane; Cell membrane; Complete proteome; Glycosyltransferase; Lipid A biosynthesis; Lipid biosynthesis; Lipid metabolism; Lipopolysaccharide biosynthesis; Membrane; Reference proteome; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 327 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0016780; F:phosphotransferase activity, for other substituted phosphate groups; IEA:HAMAP.
 GO:0016757; F:transferase activity, transferring glycosyl groups; IEA:UniProtKB-KW.
 GO:0036108; P:4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0009245; P:lipid A biosynthetic process; IEA:HAMAP.
 GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW. 

Interpro

 IPR022857; ArnC_tfrase.
 IPR001173; Glyco_trans_2. 

Pfam

 PF00535; Glycos_transf_2 

SMART

  

PROSITE

  

PRINTS