CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009928
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ribosome maturation protein SBDS 
Protein Synonyms/Alias
 Protein 22A3; Shwachman-Bodian-Diamond syndrome protein homolog 
Gene Name
 Sbds 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
62SVFVNVSKGQVAKKEubiquitination[1]
90ICKQILTKGEVQVSDubiquitination[1]
98GEVQVSDKERHTQLEubiquitination[1]
118IATIVADKCVNPETKubiquitination[1]
151VKPNKSTKQQALEVIubiquitination[1]
159QQALEVIKQLKEKMKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, triggers the GTP- dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation (By similarity). 
Sequence Annotation
 MOD_RES 2 2 N-acetylserine (By similarity).  
Keyword
 Acetylation; Complete proteome; Cytoplasm; Cytoskeleton; Nucleus; Reference proteome; Ribosome biogenesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 250 AA 
Protein Sequence
MSIFTPTNQI RLTNVAVVRM KRGGKRFEIA CYKNKVVGWR SGVEKDLDEV LQTHSVFVNV 60
SKGQVAKKED LISAFGTDDQ TEICKQILTK GEVQVSDKER HTQLEQMFRD IATIVADKCV 120
NPETKRPYTV ILIERAMKDI HYSVKPNKST KQQALEVIKQ LKEKMKIERA HMRLRFILPV 180
NEGKKLKEKL KPLMKVVESE DYSQQLEIVC LIDPGCFREI DELIKKETKG RGSLEVLSLK 240
DVEEGDEKFE 250 
Gene Ontology
 GO:0005737; C:cytoplasm; IBA:RefGenome.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IBA:RefGenome.
 GO:0000922; C:spindle pole; ISS:UniProtKB.
 GO:0043022; F:ribosome binding; ISS:UniProtKB.
 GO:0003723; F:RNA binding; IBA:RefGenome.
 GO:0019843; F:rRNA binding; IEA:Compara.
 GO:0048539; P:bone marrow development; IEA:Compara.
 GO:0030282; P:bone mineralization; IEA:Compara.
 GO:0001833; P:inner cell mass cell proliferation; IMP:MGI.
 GO:0030595; P:leukocyte chemotaxis; IEA:Compara.
 GO:0042256; P:mature ribosome assembly; ISS:UniProtKB.
 GO:0043148; P:mitotic spindle stabilization; IEA:Compara.
 GO:0042273; P:ribosomal large subunit biogenesis; IBA:RefGenome.
 GO:0006364; P:rRNA processing; IBA:RefGenome. 
Interpro
 IPR018978; Ribosome_mat_SBDS_C.
 IPR018023; Ribosome_mat_SBDS_CS.
 IPR019783; Ribosome_mat_SBDS_N.
 IPR002140; Ribosome_maturation_pr_SBDS. 
Pfam
 PF01172; SBDS
 PF09377; SBDS_C 
SMART
  
PROSITE
 PS01267; UPF0023 
PRINTS