CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016486
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nuclear pore complex protein Nup93 
Protein Synonyms/Alias
 93 kDa nucleoporin; CBP-interacting protein 4; Nucleoporin Nup93 
Gene Name
 Nup93 
Gene Synonyms/Alias
 Cip4; Kiaa0095 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
59SQETADVKASVLLGSubiquitination[1]
94FEPLEPVKDTDIQGFubiquitination[1]
103TDIQGFLKNEKDNALacetylation[2]
106QGFLKNEKDNALLSAacetylation[3]
243TPATDALKSRSSVEVubiquitination[1]
359FQEYMNSKDRRLSPAubiquitination[1]
370LSPATENKLRLHYRRubiquitination[1]
611DTKPIINKVASVAENubiquitination[1]
619VASVAENKGLFEEAAubiquitination[1]
627GLFEEAAKLYDLAKNubiquitination[1]
644KVLELMNKLLSPVVPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC (By similarity). 
Sequence Annotation
 MOD_RES 52 52 Phosphoserine (By similarity).
 MOD_RES 72 72 Phosphoserine (By similarity).
 MOD_RES 75 75 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Membrane; mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein; Protein transport; Reference proteome; Translocation; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 819 AA 
Protein Sequence
MDTEGFGELL QQAEQLAAET EGISELPHVE RNLQEIQQAG ERLRSRTLTR TSQETADVKA 60
SVLLGSRGLD ISHISQRLES LSAATTFEPL EPVKDTDIQG FLKNEKDNAL LSAIEESRKR 120
TFGMAEEYHR ESMLVEWEQV KQRILHTLLA SGEDALDFTQ ESEPSYIGDV NPPGRSSLDS 180
IEMAYARQIY IYNEKIVSGH LQPNLVDLCA SVAELDDKSI SDMWAMVKQM TDVVLTPATD 240
ALKSRSSVEV RMDFVKQALG YLEQSYKNYT LVTVFGNLHQ AQLGGVPGTY QLVRSFLNIK 300
LPAPSPGLQD GEVEGHPVWA LIYYCMRCGD LLAASQVVSR AQHQLGEFKT WFQEYMNSKD 360
RRLSPATENK LRLHYRRALR NNTDPYKRAV YCIIGRCDIT DNQSEVADKT EDYLWLKLNQ 420
VCFDDDGTSS PQDRLTLSQF QKQLLEDYGE SHFTVNQQPF LYFQVLFLTA QFEAAIAFLF 480
RMERLRCHAV HVALVLFELK LLLKSSGQSA QLLSHEPGDP PCMRRLNFVR LLMLYTRKFE 540
STDPREALQY FYFLRDEKDS QGENMFLRCV SELVIESREF DMILGKLEND GSRKPGVIDK 600
FTSDTKPIIN KVASVAENKG LFEEAAKLYD LAKNADKVLE LMNKLLSPVV PQISAPQSNK 660
ERLKNMALSI AERYRAQGIS ANKFVDSTFY LLLDLITFFD EYHSGHIDRA FDIIDRLKLV 720
PLNQESVEER VAAFRNFSDE IRHNLSEVLL ATMNILFTQF KRLKGTSPSS ATRPQRVIED 780
RDSQLRSQAR ALITFAGMIP YRTSGDTNAR LVQMEVLMN 819 
Gene Ontology
 GO:0031965; C:nuclear membrane; ISS:UniProtKB.
 GO:0034399; C:nuclear periphery; ISS:UniProtKB.
 GO:0005643; C:nuclear pore; ISS:UniProtKB.
 GO:0017056; F:structural constituent of nuclear pore; ISS:UniProtKB.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0051292; P:nuclear pore complex assembly; ISS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 
Interpro
 IPR007231; Nucleoporin_int_Nup93/Nic96. 
Pfam
 PF04097; Nic96 
SMART
  
PROSITE
  
PRINTS