CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044200
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Segment polarity protein dishevelled homolog DVL-2 
Protein Synonyms/Alias
  
Gene Name
 DVL2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
58AGAKYFFKSMDQDFGubiquitination[1]
347PIVLTVAKCWDPSPQubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 730 AA 
Protein Sequence
MAGSSTGGGG VGETKVIYHL DEEETPYLVK IPVPAERITL GDFKSVLQRP AGAKYFFKSM 60
DQDFGVVKEE ISDDNARLPC FNGRVVSWLV SSDNPQPEMA PPVHEPRAEL APPAPPLPPL 120
PPERTSGIGD SRPPSFHHEN LEPETETESV VSLRRERPRR RDSSEHGAGG HRTGGPSRLE 180
RHLAGYESSS TLMTSELEST SLGDSDEEDT MSRFSSSTEQ SSASRLLKRH RRRRKQRPPR 240
LERTSSFSSV TDSTMSLNII TVTLNMEKYN FLGISIVGQS NERGDGGIYI GSIMKGGAVA 300
ADGRIEPGDM LLQVNDMNFE NMSNDDAVRV LRDIVHKPGP IVLTVAKCWD PSPQAYFTLP 360
RNEPIQPIDP AAWVSHSAAL TGTFPAYPGS SSMSTITSGS SLPDGCEGRG LSVHTDMASV 420
TKAMAAPESG LEVRDRMWLK ITIPNAFLGS DVVDWLYHHV EGFPERREAR KYASGLLKAG 480
LIRHTVNKIT FSEQCYYVFG DLSGGCESYL VNLSLNDNDG SSGASDQDTL APLPGATPWP 540
LLPTFSYQYP APHPYSPQPP PYHELSSYTY GGGSASSQHS EGSRSSGSTR SDGGAGRTGR 600
PEERAPESKS GSGSESEPSS RGGSLRRGGE ASGTSDGGPP PSRGSTGGAP NLRAHPGLHP 660
YGPPPGMALP YNPMMVVMMP PPPPPVPPAV QPPGAPPVRD LGSVPPELTA SRQSFHMAMG 720
NPSEFFVDVM 730 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0007275; P:multicellular organismal development; IEA:InterPro. 
Interpro
 IPR000591; DEP_dom.
 IPR008341; Dishevelled_2.
 IPR024580; Dishevelled_C-dom.
 IPR008339; Dishevelled_fam.
 IPR003351; Dishevelled_protein_dom.
 IPR001158; DIX.
 IPR015506; Dsh/Dvl-rel.
 IPR001478; PDZ.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF00610; DEP
 PF02377; Dishevelled
 PF00778; DIX
 PF12316; Dsh_C
 PF00595; PDZ 
SMART
 SM00021; DAX
 SM00049; DEP
 SM00228; PDZ 
PROSITE
 PS50186; DEP
 PS50841; DIX
 PS50106; PDZ 
PRINTS
 PR01760; DISHEVELLED.
 PR01762; DISHEVELLED2.