UniProt Accession

 B4DJV2_HUMAN; B4DJV2 

Genbank Protein ID

 AC073896; AK296249 

Genbank Nucleotide ID

 BAG58964.1 

Protein Name

 Citrate synthase 

Protein Synonyms/Alias

  

Gene Name

 CS 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
21	SASSTNLKDILADLI	ubiquitination	[1]
30	ILADLIPKEQARIKT	acetylation	[2]
30	ILADLIPKEQARIKT	ubiquitination	[1, 3]
63	YGGMRGMKGLVYETS	acetylation	[2]
63	YGGMRGMKGLVYETS	ubiquitination	[1, 4]
90	FSIPECQKLLPKAKG	acetylation	[2, 5, 6]
90	FSIPECQKLLPKAKG	ubiquitination	[3, 4, 6]
308	QLQKEVGKDVSDEKL	acetylation	[2, 5]
314	GKDVSDEKLRDYIWN	acetylation	[5, 6]
314	GKDVSDEKLRDYIWN	ubiquitination	[3]
353	CQREFALKHLPNDPM	acetylation	[2, 5]
353	CQREFALKHLPNDPM	ubiquitination	[1, 4]
362	LPNDPMFKLVAQLYK	acetylation	[2, 5]
369	KLVAQLYKIVPNVLL	acetylation	[2, 5]
369	KLVAQLYKIVPNVLL	ubiquitination	[1, 3, 4, 7]
380	NVLLEQGKAKNPWPN	ubiquitination	[1]
382	LLEQGKAKNPWPNVD	ubiquitination	[4]
437	GFPLERPKSMSTEGL	acetylation	[6]
437	GFPLERPKSMSTEGL	ubiquitination	[1]
446	MSTEGLMKFVDSKSG	acetylation	[2, 5]
446	MSTEGLMKFVDSKSG	ubiquitination	[3]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [7] A data set of human endogenous protein ubiquitination sites.
 Shi Y, Chan DW, Jung SY, Malovannaya A, Wang Y, Qin J.
 Mol Cell Proteomics. 2011 May;10(5):M110.002089. [PMID: 20972266] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 453 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0004108; F:citrate (Si)-synthase activity; IEA:InterPro.
 GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.
 GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro. 

Interpro

 IPR016142; Citrate_synth-like_lrg_a-sub.
 IPR002020; Citrate_synthase-like.
 IPR016141; Citrate_synthase-like_core.
 IPR019810; Citrate_synthase_AS.
 IPR010109; Citrate_synthase_euk. 

Pfam

 PF00285; Citrate_synt 

SMART

  

PROSITE

 PS00480; CITRATE_SYNTHASE 

PRINTS

 PR00143; CITRTSNTHASE.