UniProt Accession

 SOX12_HUMAN; O15370; Q5D038; Q9NUD4 

Genbank Protein ID

 U35612; AL034548; BC067361 

Genbank Nucleotide ID

 AAB69627.1; CAB81632.1; AAH67361.1 

Protein Name

 Transcription factor SOX-12 

Protein Synonyms/Alias

 Protein SOX-22 

Gene Name

 SOX12 

Gene Synonyms/Alias

 SOX22 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
99	EAERLRLKHMADYPD	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Binds to the sequence 5'-AACAAT-3' (By similarity). 

Sequence Annotation

 DNA_BIND 40 108 HMG box.  

Keyword

 Complete proteome; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 315 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0032993; C:protein-DNA complex; IEA:Compara.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; ISS:UniProtKB.
 GO:0001105; F:RNA polymerase II transcription coactivator activity; ISS:UniProtKB.
 GO:0000976; F:transcription regulatory region sequence-specific DNA binding; ISS:UniProtKB.
 GO:0045165; P:cell fate commitment; IEP:UniProtKB.
 GO:0065004; P:protein-DNA complex assembly; IEA:Compara.
 GO:0021510; P:spinal cord development; ISS:UniProtKB. 

Interpro

 IPR009071; HMG_box_dom.
 IPR017386; SOX-12/11/4a. 

Pfam

 PF00505; HMG_box 

SMART

 SM00398; HMG 

PROSITE

 PS50118; HMG_BOX_2 

PRINTS