CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031278
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Calponin-2 
Protein Synonyms/Alias
 cDNA FLJ52765, highly similar to Calponin-2 
Gene Name
 CNN2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
8MSSTQFNKGPSYGLSubiquitination[1, 2]
19YGLSAEVKNRLLSKYubiquitination[2, 3]
25VKNRLLSKYDPQKEAubiquitination[2, 3, 4]
30LSKYDPQKEAELRTWubiquitination[2]
55PDFQKGLKDGTILCTubiquitination[2, 3]
66ILCTLMNKLQPGSVPubiquitination[2]
74LQPGSVPKINRSMQNubiquitination[2]
155SLTQAKTKGLQSGVDubiquitination[2]
181NFDDATMKAGQCVIGubiquitination[2]
195GLQMGTNKCASQSGMubiquitination[2]
255RRHIYDTKLGTDKCDubiquitination[2]
260DTKLGTDKCDNSSMSubiquitination[2]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 330 AA 
Protein Sequence
MSSTQFNKGP SYGLSAEVKN RLLSKYDPQK EAELRTWIEG LTGLSIGPDF QKGLKDGTIL 60
CTLMNKLQPG SVPKINRSMQ NWHQLENLSN FIKAMVSYGM NPVDLFEAND LFESGNMTQV 120
QVSLLALAGK GLDLGSLAAL CWYSRPLSLT QAKTKGLQSG VDIGVKYSEK QERNFDDATM 180
KAGQCVIGLQ MGTNKCASQS GMTAYGTRRH LYDPKNHILP PMDHSTISLQ MGTNKCASQV 240
GMTAPGTRRH IYDTKLGTDK CDNSSMSLQM GYTQGANQSG QVFGLGRQIY DPKYCPQGTV 300
ADGAPSGTGD CPDPGEVPEY PPYYQEEAGY 330 
Gene Ontology
 GO:0031032; P:actomyosin structure organization; IEA:InterPro. 
Interpro
 IPR001997; Calponin.
 IPR000557; Calponin_repeat.
 IPR001715; CH-domain.
 IPR003096; SM22_calponin. 
Pfam
 PF00402; Calponin
 PF00307; CH 
SMART
 SM00033; CH 
PROSITE
 PS01052; CALPONIN_1
 PS51122; CALPONIN_2
 PS50021; CH 
PRINTS
 PR00889; CALPONIN.
 PR00888; SM22CALPONIN.