CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008721
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transcription regulatory protein SNF12 
Protein Synonyms/Alias
 SWI/SNF complex component SWP73 
Gene Name
 SNF12 
Gene Synonyms/Alias
 SWP73; YNR023W; N3224 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
201NDNVPSTKFNAAPEEacetylation[1]
499SNLHESNKRYRFFKKubiquitination[2]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Involved in transcriptional activation. Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors. 
Sequence Annotation
  
Keyword
 Activator; Complete proteome; Nucleus; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 566 AA 
Protein Sequence
MSKVMKPSNG KGSRKSSKAA TPDTKNFFHA KKKDPVNQDK ANNASQITPT VPHSHPSDMV 60
IPDHLAELIP ELYSFQQLVD SEKRLDHFIH LRNLHMKRMV AQWERSKLSQ EFLYPHLNFP 120
NVKFLRIFIS NVSENQPWQM DTNNEADLMA LENATWTMRI EGRLLDNVQA NDPAREKFSS 180
FIESIVVDFK NKENDNVPST KFNAAPEENA TEGPSDKKLN LNLPLQFSLP NGDNSTTTNT 240
DQNNATMGEE TAKKDMSSTT PKLESVKWQY DPNNPVDFDG LDIKRVGSEN VECTISILRK 300
SSPEEPFMSY SPQLTAIIGL KSGTSHDAIF SIYKYIHLNE LLTNDESAFE NLMGNRNNHN 360
SNTSTSKMLD AASSQVSIVK LDTQLITLLP SSLKESSPDT MKLTDLLSLI NSTHLLPLQP 420
IEIDYTVRVD KASTYGELVL DIEVPDVNAL KFNNTQRESQ IGAAELNENA RELEQIKPKI 480
ALQDKEITSV LSNLHESNKR YRFFKKISED PVKALNECIA STSNALKVLS GDEGYNEDMV 540
RRANFYKENE AMLRENIEVI LSNGRM 566 
Gene Ontology
 GO:0005829; C:cytosol; IDA:SGD.
 GO:0016514; C:SWI/SNF complex; IMP:UniProtKB.
 GO:0061412; P:positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation; IMP:SGD.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR003121; SWIB_MDM2_domain. 
Pfam
  
SMART
  
PROSITE
  
PRINTS