UniProt Accession

 TMM18_HUMAN; Q96B42; D6W4X9; Q8N5H2; Q9NTH3 

Genbank Protein ID

 AL137269; AC092159; CH471053; CH471053; BC016010; BC032379 

Genbank Nucleotide ID

 CAB70668.1; AAY14770.1; EAX01100.1; EAX01101.1; AAH16010.2; AAH32379.1 

Protein Name

 Transmembrane protein 18 

Protein Synonyms/Alias

  

Gene Name

 TMEM18 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
82	MNWRLFSKYQYFDSR	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC). 

Sequence Annotation

 REGION 113 140 DNA-binding.
 MOTIF 130 138 Nuclear localization signal.  

Keyword

 Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; DNA-binding; Membrane; Nucleus; Reference proteome; Transcription; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 140 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031965; C:nuclear membrane; IDA:UniProtKB.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0016477; P:cell migration; IDA:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR026721; TMEM18. 

Pfam

  

SMART

  

PROSITE

  

PRINTS