CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004780
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glutamate receptor 3 
Protein Synonyms/Alias
 GluR-3; AMPA-selective glutamate receptor 3; GluR-C; GluR-K3; Glutamate receptor ionotropic, AMPA 3; GluA3 
Gene Name
 Gria3 
Gene Synonyms/Alias
 Glur3 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
861TKNTQNFKPAPATNTubiquitination[1]
887VYGTESVKI******ubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity). 
Sequence Annotation
 REGION 502 504 Glutamate binding.
 REGION 680 681 Glutamate binding.
 BINDING 474 474 Glutamate.
 BINDING 509 509 Glutamate.
 BINDING 731 731 Glutamate.
 MOD_RES 871 871 Phosphotyrosine (By similarity).
 MOD_RES 881 881 Phosphotyrosine (By similarity).
 LIPID 615 615 S-palmitoyl cysteine (By similarity).
 LIPID 841 841 S-palmitoyl cysteine (By similarity).
 CARBOHYD 57 57 N-linked (GlcNAc...) (Potential).
 CARBOHYD 260 260 N-linked (GlcNAc...).
 CARBOHYD 374 374 N-linked (GlcNAc...).
 CARBOHYD 409 409 N-linked (GlcNAc...) (Potential).
 CARBOHYD 416 416 N-linked (GlcNAc...) (Potential).
 DISULFID 85 334
 DISULFID 744 799  
Keyword
 3D-structure; Alternative splicing; Cell junction; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Postsynaptic cell membrane; Receptor; Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 888 AA 
Protein Sequence
MGQSVLRAVF FLVLGLLGHS HGGFPNTISI GGLFMRNTVQ EHSAFRFAVQ LYNTNQNTTE 60
KPFHLNYHVD HLDSSNSFSV TNAFCSQFSR GVYAIFGFYD QMSMNTLTSF CGALHTSFVT 120
PSFPTDADVQ FVIQMRPALK GAILSLLSYY KWEKFVYLYD TERGFSVLQA IMEAAVQNNW 180
QVTARSVGNI KDVQEFRRII EEMDRRQEKR YLIDCEVERI NTILEQVVIL GKHSRGYHYM 240
LANLGFTDIL LERVMHGGAN ITGFQIVNNE NPMVQQFIQR WVRLDEREFP EAKNAPLKYT 300
SALTHDAILV IAEAFRYLRR QRVDVSRRGS AGDCLANPAV PWSQGIDIER ALKMVQVQGM 360
TGNIQFDTYG RRTNYTIDVY EMKVSGSRKA GYWNEYERFV PFSDQQISND SSSSENRTIV 420
VTTILESPYV MYKKNHEQLE GNERYEGYCV DLAYEIAKHV RIKYKLSIVG DGKYGARDPE 480
TKIWNGMVGE LVYGRADIAV APLTITLVRE EVIDFSKPFM SLGISIMIKK PQKSKPGVFS 540
FLDPLAYEIW MCIVFAYIGV SVVLFLVSRF SPYEWHLEDN NEEPRDPQSP PDPPNEFGIF 600
NSLWFSLGAF MQQGCDISPR SLSGRIVGGV WWFFTLIIIS SYTANLAAFL TVERMVSPIE 660
SAEDLAKQTE IAYGTLDSGS TKEFFRRSKI AVYEKMWSYM KSAEPSVFTK TTADGVARVR 720
KSKGKFAFLL ESTMNEYIEQ RKPCDTMKVG GNLDSKGYGV ATPKGSALGN AVNLAVLKLN 780
EQGLLDKLKN KWWYDKGECG SGGGDSKDKT SALSLSNVAG VFYILVGGLG LAMMVALIEF 840
CYKSRAESKR MKLTKNTQNF KPAPATNTQN YATYREGYNV YGTESVKI 888 
Gene Ontology
 GO:0032281; C:alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex; IDA:UniProtKB.
 GO:0032279; C:asymmetric synapse; IDA:RGD.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0043198; C:dendritic shaft; IDA:RGD.
 GO:0043204; C:perikaryon; IDA:RGD.
 GO:0014069; C:postsynaptic density; IDA:UniProtKB.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0043083; C:synaptic cleft; IDA:RGD.
 GO:0043195; C:terminal bouton; IDA:RGD.
 GO:0004971; F:alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; IDA:RGD.
 GO:0005234; F:extracellular-glutamate-gated ion channel activity; IEA:InterPro.
 GO:0001919; P:regulation of receptor recycling; IMP:UniProtKB.
 GO:0060992; P:response to fungicide; IEP:RGD.
 GO:0010226; P:response to lithium ion; IEP:UniProtKB. 
Interpro
 IPR001828; ANF_lig-bd_rcpt.
 IPR019594; Glu_rcpt_Glu/Gly-bd.
 IPR001320; Iontro_glu_rcpt.
 IPR001508; NMDA_rcpt. 
Pfam
 PF01094; ANF_receptor
 PF00060; Lig_chan
 PF10613; Lig_chan-Glu_bd 
SMART
 SM00918; Lig_chan-Glu_bd
 SM00079; PBPe 
PROSITE
  
PRINTS
 PR00177; NMDARECEPTOR.