CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030776
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 F-actin-capping protein subunit alpha-2 
Protein Synonyms/Alias
 cDNA FLJ51827, highly similar to F-actin capping protein alpha-2 subunit 
Gene Name
 CAPZA2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
13EQLSDEEKVRIAAKFubiquitination[1]
19EKVRIAAKFIIHAPPubiquitination[1, 2, 3]
86HGDLGNGKFLDPKNRacetylation[4, 5, 6]
86HGDLGNGKFLDPKNRubiquitination[3]
91NGKFLDPKNRICFKFubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 172 AA 
Protein Sequence
MADLEEQLSD EEKVRIAAKF IIHAPPGEFN EVFNDVRLLL NNDNLLREGA AHAFAQYNLD 60
QFTPVKIEGY EDQVLITEHG DLGNGKFLDP KNRICFKFDH LRKEATDPRP CEVENAVESW 120
RTSVETALRA YVKEHYPNGV CTEWSLEVRM EVYNHSFNHS SGWHLENSGS LL 172 
Gene Ontology
 GO:0008290; C:F-actin capping protein complex; IEA:InterPro.
 GO:0030036; P:actin cytoskeleton organization; IEA:InterPro. 
Interpro
 IPR002189; WASH_F-actin_cap_alpha. 
Pfam
 PF01267; F-actin_cap_A 
SMART
  
PROSITE
  
PRINTS