UniProt Accession

 DECR_HUMAN; Q16698; Q2M304; Q93085 

Genbank Protein ID

 L26050; U49352; U78302; U94980; U94981; U94982; U94983; U94984; U94985; U94986; U94987; AC004612; AF049895; BC105080; BC105082 

Genbank Nucleotide ID

 AAA67551.1; AAB09423.1; AAB88724.1; AAB88724.1; AAB88724.1; AAB88724.1; AAB88724.1; AAB88724.1; AAB88724.1; AAB88724.1; AAB88724.1; AAC14671.1; AAI05081.1; AAI05083.1 

Protein Name

 2,4-dienoyl-CoA reductase, mitochondrial 

Protein Synonyms/Alias

 2,4-dienoyl-CoA reductase [NADPH]; 4-enoyl-CoA reductase [NADPH] 

Gene Name

 DECR1 

Gene Synonyms/Alias

 DECR 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
42	NTEALQSKFFSPLQK	ubiquitination	[1]
222	AGVEAMSKSLAAEWG	ubiquitination	[1, 2]
230	SLAAEWGKYGMRFNV	acetylation	[3]
260	DPTGTFEKEMIGRIP	acetylation	[4]
260	DPTGTFEKEMIGRIP	ubiquitination	[2]
319	NDLRKVTKEQWDTIE	ubiquitination	[2]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [4] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA. 

Sequence Annotation

 NP_BIND 66 71 NADP.
 NP_BIND 240 243 NADP.
 ACT_SITE 199 199 Proton acceptor (Potential).
 BINDING 91 91 NADP.
 BINDING 91 91 Substrate (By similarity).
 BINDING 117 117 NADP.
 BINDING 119 119 Substrate.
 BINDING 149 149 Substrate.
 BINDING 157 157 Substrate.
 BINDING 214 214 NADP.
 BINDING 251 251 Substrate (By similarity).
 MOD_RES 110 110 N6-acetyllysine (By similarity).
 MOD_RES 230 230 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Fatty acid metabolism; Lipid metabolism; Mitochondrion; NADP; Oxidoreductase; Polymorphism; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 335 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; TAS:Reactome.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0008670; F:2,4-dienoyl-CoA reductase (NADPH) activity; IDA:UniProtKB.
 GO:0070402; F:NADPH binding; IDA:UniProtKB.
 GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; TAS:Reactome.
 GO:0006635; P:fatty acid beta-oxidation; IDA:UniProtKB.
 GO:0051289; P:protein homotetramerization; IDA:UniProtKB. 

Interpro

 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom. 

Pfam

  

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.