| Tag | Content |
|---|
| CPLM ID | CPLM-001856 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Trifunctional purine biosynthetic protein adenosine-3 |
Protein Synonyms/Alias | Phosphoribosylamine--glycine ligase; Glycinamide ribonucleotide synthetase; GARS; Phosphoribosylglycinamide synthetase; Phosphoribosylformylglycinamidine cyclo-ligase; AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase; Phosphoribosylglycinamide formyltransferase; 5'-phosphoribosylglycinamide transformylase; GAR transformylase; GART |
Gene Name | ade3 |
Gene Synonyms/Alias | Gart; CG31628 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 135 | ESFTDTEKAKAFIRS | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | |
Sequence Annotation | DOMAIN 114 321 ATP-grasp.
NP_BIND 140 202 ATP (By similarity).
REGION 434 1152 AIRS.
REGION 1153 1353 GART.
REGION 1164 1166 5'-phosphoribosylglycinamide binding (By
REGION 1244 1247 10-formyltetrahydrofolate binding (By
REGION 1295 1299 10-formyltetrahydrofolate binding (By
REGION 1325 1328 5'-phosphoribosylglycinamide binding (By
ACT_SITE 1263 1263 Proton donor (By similarity).
METAL 291 291 Manganese (By similarity).
METAL 293 293 Manganese (By similarity).
BINDING 1219 1219 10-formyltetrahydrofolate (By
BINDING 1261 1261 10-formyltetrahydrofolate (By
MOD_RES 814 814 Phosphoserine.
MOD_RES 816 816 Phosphoserine. |
Keyword | Alternative splicing; ATP-binding; Complete proteome; Ligase; Manganese; Metal-binding; Multifunctional enzyme; Nucleotide-binding; Phosphoprotein; Purine biosynthesis; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1353 AA |
Protein Sequence | MSHRVLVIGS GGREHAICWK LSQSPKVAQI YALPGSHGIQ LVEKCRNLDA KTLDPKDFEA 60
IAKWSKENQI ALVVVGPEDP LALGLGDVLQ SAGIPCFGPG KQGAQIEADK KWAKDFMLRH 120
GIPTARYESF TDTEKAKAFI RSAPYPALVV KAAGLAAGKG VVVAANAKEA CQAVDEILGD 180
LKYGQAGATL VVEELLEGEE VSVLAFTDGK SVRAMLPAQD HKRLGNGDTG PNTGGMGAYC 240
PCPLISQPAL ELVQKAVLER AVQGLIKERI NYQGVLYAGL MLTRDGPRVL EFNCRFGDPE 300
TQVILPLLES DLFDVMEACC SGKLDKIPLQ WRNGVSAVGV ILASAGYPET STKGCIISGL 360
PAANTPTQLV FHSGLAVNAQ KEALTNGGRV LIAIALDGSL KEAAAKATKL AGSISFSGSG 420
AQYRTDIAQK AFKIASASTP GLSYKDSGVD IDAGDALVQR IKPLSRGTQR PGVIGGLGGF 480
GGLFRLKELT YKEPVIAEAT QGVGAKIHLA LTHEFYENVG YDLFALAAND VLEVGAEPVA 540
FLDYIACGKL QVPLAAQLVK GMADGCRDAR CALVGGETAE MPSLYAPGQH DMAGYCVGIV 600
EHSRILPRFD LYQPGDLLIG LPSSGLHCAG FNEILTQLAA SKVNLRERSP VDGGDDGLTL 660
AHVLATPTQL YVQQLLPHLQ KGDEIKSVAH VTHGLLNDIL RLLPDGFETT LDFGAVPVPK 720
IFGWLAGKLK LSAQTILERH NCGIGMVLIL PQSSQLWRTS LPGAKVLGVL QRRSKVSGSP 780
VQVRNFVEQL EKVASPFGGL GDRELPEELK KLPSNSDLSA PREECFENAA GRRLTRIPTH 840
YKDPILILGT DGVGTKLKIA QQTNRNTSVG IDLVAMCVND ILCNGAEPIS FSSYYACGHW 900
QEQLAKGVHS GVQEGARQAN SSFIDSHSAA LPLLYEPQVY DLAGFALGIA EHTGILPLLA 960
EIQPGDVLIG LPSSGVHSNG FSLVHAVLKR VGLGLHDKAP FSDKTLGEEL LVPTKIYVKA 1020
LSTLLSRGKH GIKALAHITG GGLSENIPRV LRKDLAVRLD ANKFQLPPVF AWLAAAGNIS 1080
STELQRTYNC GLGMVLVVAP TEVEDVLKEL RYPQRAAVVG EVVARKDPKK SQVVVQNFEA 1140
SLARTQKMLS QRRKRVAVLI SGTGSNLQAL IDATRDSAQG IHADVVLVIS NKPGVLGLQR 1200
ATQAGIPSLV ISHKDFASRE VYDAELTRNL KAARVDLICL AGFMRVLSAP FVREWRGRLV 1260
NIHPSLLPKY PGLHVQKQAL EAGEKESGCT VHFVDEGVDT GAIIVQAAVP ILPDDDEDSL 1320
TQRIHKAEHW AFPRALAMLV NGTALISPEV SSQ 1353 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:InterPro. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0008168; F:methyltransferase activity; IEA:InterPro. GO:0004637; F:phosphoribosylamine-glycine ligase activity; IDA:FlyBase. GO:0004641; F:phosphoribosylformylglycinamidine cyclo-ligase activity; IDA:FlyBase. GO:0004644; F:phosphoribosylglycinamide formyltransferase activity; IDA:FlyBase. GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway. GO:0032259; P:methylation; IEA:GOC. GO:0009113; P:purine nucleobase biosynthetic process; IC:FlyBase. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |