| Tag | Content |
|---|
| CPLM ID | CPLM-012788 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Shugoshin |
Protein Synonyms/Alias | Meiotic protein S332 |
Gene Name | mei-S332 |
Gene Synonyms/Alias | CG5303 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 4 | ****MGSKVEQQYKL | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Plays a central role in chromosome cohesion during meiosis and mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by protecting or Rad21 from cleavage by Sse/separase. Required during meiosis in both males and females. |
Sequence Annotation | MOD_RES 124 124 Phosphoserine; by ial (Probable).
MOD_RES 125 125 Phosphoserine; by ial (Probable).
MOD_RES 126 126 Phosphoserine; by ial (Probable).
MOD_RES 331 331 Phosphothreonine; by PLK1 (Probable). |
Keyword | Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition; Coiled coil; Complete proteome; Developmental protein; Meiosis; Mitosis; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 401 AA |
Protein Sequence | MGSKVEQQYK LLNAELMDQV QKQRLEIGEY RKRVISLERE IMDIREEHVL QNHRQRMENI 60
SIVRSLMLSL NVDSDSLAVR QEPAPAAQIN RPSGPRRSSR EICKDMRRTC ALARTTRPIS 120
PRRSSSVTST VSSTSRRSSA EVQSEVVTTR IPEDRRANKP TPPPRRPAEL VFDEDDSDDD 180
FDEAVSPVEE TQTEQNEENN RLFSIIEENG SEGESTDSSS SCEAIYCDTT FESSPPNAQV 240
TVTPSGRALR EVDTNIPVAV SLSRGKETGK GSWLAISVAV EDSPQEPSIQ CPRLAVTRPS 300
QSSGIFPDVN GLTPRRSLFN GIGKMAGSTS TPKSFLVEEM PSIRTRSRTA ANKKSENTDM 360
SSSFCNNSAR PSRSCRPTSL VEPSLKNKLR NGSKGKAKAK K 401 |
Gene Ontology | GO:0000780; C:condensed nuclear chromosome, centromeric region; IDA:FlyBase. GO:0051301; P:cell division; IEA:UniProtKB-KW. GO:0007143; P:female meiosis; IMP:FlyBase. GO:0007065; P:male meiosis sister chromatid cohesion; IEP:FlyBase. GO:0007067; P:mitosis; IEA:UniProtKB-KW. GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. |
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PRINTS | |