CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016248
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tax1-binding protein 1 
Protein Synonyms/Alias
 TRAF6-binding protein 
Gene Name
 TAX1BP1 
Gene Synonyms/Alias
 T6BP; PRO0105 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
332LQLCLAEKENLQRTFubiquitination[1]
375QEVVFLAKELSDAVNubiquitination[1]
465RLQKQINKLSDQSANubiquitination[1, 2]
534MTKEIADKTEKYNKCubiquitination[3]
537EIADKTEKYNKCKQLubiquitination[3]
540DKTEKYNKCKQLLQDubiquitination[3]
561KYADELAKMELKWKEubiquitination[1, 2, 3]
567AKMELKWKEQVKIAEubiquitination[1]
571LKWKEQVKIAENVKLubiquitination[1, 3]
588AEVQDNYKELKRSLEubiquitination[3, 4]
591QDNYKELKRSLENPAubiquitination[1]
601LENPAERKMEGQNSQubiquitination[3]
695LEDSEDSKEDENVPTubiquitination[3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade. 
Sequence Annotation
 REGION 320 420 Oligomerization.
 MOD_RES 225 225 Phosphoserine.
 MOD_RES 593 593 Phosphoserine; by IKKA.
 MOD_RES 666 666 Phosphoserine; by IKKA.  
Keyword
 Alternative splicing; Apoptosis; Coiled coil; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 789 AA 
Protein Sequence
MTSFQEVPLQ TSNFAHVIFQ NVAKSYLPNA HLECHYTLTP YIHPHPKDWV GIFKVGWSTA 60
RDYYTFLWSP MPEHYVEGST VNCVLAFQGY YLPNDDGEFY QFCYVTHKGE IRGASTPFQF 120
RASSPVEELL TMEDEGNSDM LVVTTKAGLL ELKIEKTMKE KEELLKLIAV LEKETAQLRE 180
QVGRMERELN HEKERCDQLQ AEQKGLTEVT QSLKMENEEF KKRFSDATSK AHQLEEDIVS 240
VTHKAIEKET ELDSLKDKLK KAQHEREQLE CQLKTEKDEK ELYKVHLKNT EIENTKLMSE 300
VQTLKNLDGN KESVITHFKE EIGRLQLCLA EKENLQRTFL LTTSSKEDTC FLKEQLRKAE 360
EQVQATRQEV VFLAKELSDA VNVRDRTMAD LHTARLENEK VKKQLADAVA ELKLNAMKKD 420
QDKTDTLEHE LRREVEDLKL RLQMAADHYK EKFKECQRLQ KQINKLSDQS ANNNNVFTKK 480
TGNQQKVNDA SVNTDPATSA STVDVKPSPS AAEADFDIVT KGQVCEMTKE IADKTEKYNK 540
CKQLLQDEKA KCNKYADELA KMELKWKEQV KIAENVKLEL AEVQDNYKEL KRSLENPAER 600
KMEGQNSQSP QCFKTCSEQN GYVLTLSNAQ PVLQYGNPYA SQETRDGADG AFYPDEIQRP 660
PVRVPSWGLE DNVVCSQPAR NFSRPDGLED SEDSKEDENV PTAPDPPSQH LRGHGTGFCF 720
DSSFDVHKKC PLCELMFPPN YDQSKFEEHV ESHWKVCPMC SEQFPPDYDQ QVFERHVQTH 780
FDQNVLNFD 789 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0019900; F:kinase binding; ISS:BHF-UCL.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0043066; P:negative regulation of apoptotic process; TAS:ProtInc.
 GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:BHF-UCL.
 GO:0032480; P:negative regulation of type I interferon production; TAS:Reactome. 
Interpro
 IPR012852; CoCoA.
 IPR015880; Znf_C2H2-like. 
Pfam
 PF07888; CALCOCO1 
SMART
 SM00355; ZnF_C2H2 
PROSITE
  
PRINTS