| Tag | Content |
|---|
| CPLM ID | CPLM-001485 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | FERM, RhoGEF and pleckstrin domain-containing protein 2 |
Protein Synonyms/Alias | FERM domain including RhoGEF; FIR; Pleckstrin homology domain-containing family C member 3; PH domain-containing family C member 3 |
Gene Name | FARP2 |
Gene Synonyms/Alias | KIAA0793; PLEKHC3 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 49 | KHLHLRVKLLDNTME | ubiquitination | [1] | | 145 | YLFALQLKRDLLEER | ubiquitination | [1] | | 331 | DQPKPKAKAVFFSRG | ubiquitination | [1] | | 349 | RYSGRTQKQLVDYFK | ubiquitination | [1] | | 356 | KQLVDYFKDSGMKRI | ubiquitination | [1] | | 385 | ALTADLPKQSISFPE | ubiquitination | [1, 2] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] [2] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). |
Sequence Annotation | DOMAIN 44 324 FERM.
DOMAIN 535 726 DH.
DOMAIN 755 852 PH 1.
DOMAIN 929 1026 PH 2.
MOD_RES 375 375 Phosphoserine (By similarity).
MOD_RES 439 439 Phosphoserine.
MOD_RES 876 876 Phosphoserine (By similarity).
MOD_RES 881 881 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Guanine-nucleotide releasing factor; Phosphoprotein; Polymorphism; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1054 AA |
Protein Sequence | MGEIEGTYRV LQTAGMRLGA QTPVGVSTLE PGQTLLPRMQ EKHLHLRVKL LDNTMEIFDI 60
EPKCDGQVLL TQVWKRLNLV ECDYFGMEFQ NTQSYWIWLE PMKPIIRQIR RPKNVVLRLA 120
VKFFPPDPGQ LQEEYTRYLF ALQLKRDLLE ERLTCADTTA ALLTSHLLQS EIGDYDETLD 180
REHLKVNEYL PGQQHCLEKI LEFHQKHVGQ TPAESDFQVL EIARKLEMYG IRFHMASDRE 240
GTKIQLAVSH MGVLVFQGTT KINTFNWSKV RKLSFKRKRF LIKLHPEVHG PYQDTLEFLL 300
GSRDECKNFW KICVEYHTFF RLLDQPKPKA KAVFFSRGSS FRYSGRTQKQ LVDYFKDSGM 360
KRIPYERRHS KTHTSVRALT ADLPKQSISF PEGLRTPASP SSANAFYSLS PSTLVPSGLP 420
EFKDSSSSLT DPQVSYVKSP AAERRSGAVA GGPDTPSAQP LGPPALQPGP GLSTKSPQPS 480
PSSRKSPLSL SPAFQVPLGP AEQGSSPLLS PVLSDAGGAG MDCEEPRHKR VPADEAYFIV 540
KEILATERTY LKDLEVITVW FRSAVVKEDA MPATLMTLLF SNIDPIYEFH RGFLREVEQR 600
LALWEGPSKA HTKGSHQRIG DILLRNMRQL KEFTSYFQRH DEVLTELEKA TKRCKKLEAV 660
YKEFELQKVC YLPLNTFLLK PIQRLLHYRL LLRRLCGHYS PGHHDYADCH DALKAITEVT 720
TTLQHILIRL ENLQKLTELQ RDLVGIENLI APGREFIREG CLHKLTKKGL QQRMFFLFSD 780
MLLYTSKGVA GTSHFRIRGL LPLQGMLVEE SDNEWSVPHC FTIYAAQKTI VVAASTRLEK 840
EKWMLDLNSA IQAAKSGGDT APALPGRTVC TRPPRSPNEV SLEQESEDDA RGVRSSLEGH 900
GQHRANTTMH VCWYRNTSVS RADHSAAVEN QLSGYLLRKF KNSHGWQKLW VVFTNFCLFF 960
YKTHQDDYPL ASLPLLGYSV SIPREADGIH KDYVFKLQFK SHVYFFRAES KYTFERWMEV 1020
IQGASSSAGR APSIVQDGPQ PSSGLEGMVR GKEE 1054 |
Gene Ontology | GO:0005856; C:cytoskeleton; IEA:InterPro. GO:0005829; C:cytosol; TAS:Reactome. GO:0019898; C:extrinsic to membrane; IEA:InterPro. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; ISS:UniProtKB. GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB. GO:0007411; P:axon guidance; TAS:Reactome. GO:0007155; P:cell adhesion; ISS:UniProtKB. GO:0016322; P:neuron remodeling; IDA:MGI. GO:0030316; P:osteoclast differentiation; ISS:UniProtKB. GO:0071800; P:podosome assembly; ISS:UniProtKB. GO:0016601; P:Rac protein signal transduction; IDA:MGI. GO:0033623; P:regulation of integrin activation; ISS:UniProtKB. GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. GO:0071526; P:semaphorin-plexin signaling pathway; ISS:UniProtKB. |
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PROSITE | |
PRINTS | |