CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005163
UniProt Accession
Genbank Protein ID
 J05166 
Genbank Nucleotide ID
Protein Name
 Anion exchange protein 2 
Protein Synonyms/Alias
 AE 2; Anion exchanger 2; Band 3-related protein 2; B3RP-2; Non-erythroid band 3-like protein; Solute carrier family 4 member 2 
Gene Name
 Slc4a2 
Gene Synonyms/Alias
 Ae2; B3rp2 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
650PGAGLEPKSAQDKALubiquitination[1]
1073KAVAPGDKPKIQEVKacetylation[2]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Plasma membrane anion exchange protein of wide distribution. 
Sequence Annotation
 REGION 705 1234 Membrane (anion exchange).
 MOD_RES 113 113 Phosphoserine (By similarity).
 MOD_RES 145 145 Phosphoserine (By similarity).
 MOD_RES 440 440 Phosphoserine (By similarity).
 LIPID 1166 1166 S-palmitoyl cysteine (By similarity).
 CARBOHYD 856 856 N-linked (GlcNAc...) (Potential).
 CARBOHYD 866 866 N-linked (GlcNAc...) (Potential).
 CARBOHYD 878 878 N-linked (GlcNAc...) (Potential).  
Keyword
 Anion exchange; Antiport; Complete proteome; Glycoprotein; Ion transport; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1234 AA 
Protein Sequence
MSSAPRRPAS GADSLHTPEP ESLSPGTPGF PEQEEEDELR TLGVERFEEI LQEAGSRGGE 60
EPGRSYGEED FEYHRQSSHH IHHPLSTHLP PDARRRKTPQ GPGRKPRRRP GASPTGETPT 120
IEEGEEDEDE VGEAEGFRAP PQQPSPASSP SAVQFFLQED EGTDRKAERT SPSPPTQTPH 180
QEAAPRASKG AQTGTLVEEM VAVASGTAGG DDGGAAGRPL TKAQPGHRSY NLQERRRIGS 240
MTGVEQALLP RVPTDESEAQ TLATADLDLM KSHRFEDVPG VRRHLVRKNA KGSTQAAREG 300
REPGPTPRAR PRAPHKPHEV FVELNELQLD KNQEPQWRET ARWIKFEEDV EEETERWGKP 360
HVASLSFRSL LELRRTLAHG AVLLDLDQQT LPGVAHQVVE QMVISDQIKA EDRANVLRAL 420
LLKHSHPSDE KEFSFPRNIS AGSLGSLLGH HHAQGTESDP HVTEPLIGGV PETRLEVDRE 480
RELPPPAPPA GITRSKSKHE LKLLEKIPEN AEATVVLVGC VEFLSRPTMA FVRLREAVEL 540
DAVLEVPVPV RFLFLLLGPS SANMDYHEIG RSISTLMSDK QFHEAAYLAD ERDDLLTAIN 600
AFLDCSVVLP PSEVQGEELL RSVAHFQRQM LKKREEQGRL LPPGAGLEPK SAQDKALLQM 660
VEVAGAAEDD PLRRTGRPFG GLIRDVRRRY PHYLSDFRDA LDPQCLAAVI FIYFAALSPA 720
ITFGGLLGEK TQDLIGVSEL IMSTALQGVI FCLLGAQPLL VIGFSGPLLV FEEAFFSFCK 780
SNQLEYLVGR VWIGFWLVLL ALLMVALEGS FLVRFVSRFT QEIFAFLISL IFIYETFYKL 840
IKIFQEHPLH GCSVSNDSEA DSSSNNMTWA ATTLAPDNSS ASGQERPRGQ PNTALLSLVL 900
MAGTFFIAFF LRKFKNSRFF PGRIRRVIGD FGVPIAILIM VLVDYSIEDT YTQKLSVPSG 960
FSVTAPDKRG WVINPLGEKT PFPVWMMVAS LLPAVLVFIL IFMETQITTL IISKKERMLQ 1020
KGSGFHLDLL LIVAMGGICA LFGLPWLAAA TVRSVTHANA LTVMSKAVAP GDKPKIQEVK 1080
EQRVTGLLVA LLVGLSMVIG DLLRQIPLAV LFGIFLYMGV TSLNGIQFYE RLHLLLMPPK 1140
HHPDVTYVKK VRTMRMHLFT ALQLLCLALL WAVMSTAASL AFPFILILTV PLRMVVLTRI 1200
FTEREMKCLD ANEAEPVFDE CEGVDEYNEM PMPV 1234 
Gene Ontology
 GO:0016323; C:basolateral plasma membrane; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0015108; F:chloride transmembrane transporter activity; IEA:Compara.
 GO:0005452; F:inorganic anion exchanger activity; IEA:InterPro. 
Interpro
 IPR001717; Anion_exchange.
 IPR002978; Anion_exchange_2.
 IPR018241; Anion_exchange_CS.
 IPR013769; Band3_cytoplasmic_dom.
 IPR011531; HCO3_transpt_C.
 IPR003020; HCO3_transpt_euk.
 IPR016152; PTrfase/Anion_transptr. 
Pfam
 PF07565; Band_3_cyto
 PF00955; HCO3_cotransp 
SMART
  
PROSITE
 PS00219; ANION_EXCHANGER_1
 PS00220; ANION_EXCHANGER_2 
PRINTS
 PR00165; ANIONEXCHNGR.
 PR01188; ANIONEXHNGR2.
 PR01231; HCO3TRNSPORT.