UniProt Accession

 CR3L4_HUMAN; Q8TEY5; D3DV62; Q5T4L0; Q86YW6 

Genbank Protein ID

 AF394167; AF468007; AB052778; AB052781; AY049977; AK304665; AL358472; AL358472; CH471121; CH471121; CH471121; CH471121; CH471121; CH471121; BC038962 

Genbank Nucleotide ID

 AAL76113.1; AAO33070.1; BAC45035.1; BAC45224.1; AAL13157.1; BAG65440.1; CAI14026.1; CAI14027.1; EAW53251.1; EAW53253.1; EAW53254.1; EAW53256.1; EAW53257.1; EAW53258.1; AAH38962.1 

Protein Name

 Cyclic AMP-responsive element-binding protein 3-like protein 4 

Protein Synonyms/Alias

 cAMP-responsive element-binding protein 3-like protein 4; Androgen-induced basic leucine zipper protein; AIbZIP; Attaching to CRE-like 1; ATCE1; Cyclic AMP-responsive element-binding protein 4; CREB-4; cAMP-responsive element-binding protein 4; Transcript induced in spermiogenesis protein 40; Tisp40; hJAL; Processed cyclic AMP-responsive element-binding protein 3-like protein 4 

Gene Name

 CREB3L4 

Gene Synonyms/Alias

 AIBZIP; CREB4; JAL 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
51	EQGLQGWKSGGDRGC	ubiquitination	[1, 2]
194	LFLTDEEKRLLGQEG	ubiquitination	[2]
212	PSHLPLTKAEERVLK	ubiquitination	[2]
238	AQDSRRRKKEYIDGL	ubiquitination	[2]
239	QDSRRRKKEYIDGLE	ubiquitination	[2]
261	AQNQELQKKVQELER	ubiquitination	[3]
262	QNQELQKKVQELERH	ubiquitination	[2]
341	SRNILTHKDVTENLE	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity). 

Sequence Annotation

 DOMAIN 217 280 bZIP.
 REGION 219 248 Basic motif (By similarity).
 REGION 259 280 Leucine-zipper (By similarity).
 CARBOHYD 366 366 N-linked (GlcNAc...) (Potential).  

Keyword

 Activator; Alternative splicing; Complete proteome; DNA-binding; Endoplasmic reticulum; Glycoprotein; Golgi apparatus; Membrane; Nucleus; Polymorphism; Reference proteome; Signal-anchor; Transcription; Transcription regulation; Transmembrane; Transmembrane helix; Unfolded protein response. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 395 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0006986; P:response to unfolded protein; IEA:UniProtKB-KW.
 GO:0007283; P:spermatogenesis; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR004827; bZIP.
 IPR008917; Euk_TF_DNA-bd. 

Pfam

 PF00170; bZIP_1 

SMART

 SM00338; BRLZ 

PROSITE

 PS50217; BZIP 

PRINTS