UniProt Accession

 SPCS3_DROME; Q9VCA9 

Genbank Protein ID

 AE014297; AY070615 

Genbank Nucleotide ID

 AAF56264.1; AAL48086.1 

Protein Name

 Signal peptidase complex subunit 3 

Protein Synonyms/Alias

 Microsomal signal peptidase 22 kDa subunit; SPC22; SPase 22 kDa subunit 

Gene Name

 Spase22-23 

Gene Synonyms/Alias

 CG5677 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
49	NTVRVLVKNVPDYGA	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). 

Sequence Annotation

 CARBOHYD 73 73 N-linked (GlcNAc...) (Potential).
 CARBOHYD 141 141 N-linked (GlcNAc...) (Potential).  

Keyword

 Complete proteome; Endoplasmic reticulum; Glycoprotein; Hydrolase; Membrane; Microsome; Protease; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 179 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005787; C:signal peptidase complex; IEA:InterPro.
 GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0006465; P:signal peptide processing; IEA:InterPro. 

Interpro

 IPR007653; SPC22. 

Pfam

 PF04573; SPC22 

SMART

  

PROSITE

  

PRINTS