CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002508
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glyceraldehyde-3-phosphate dehydrogenase 1 
Protein Synonyms/Alias
 Glyceraldehyde-3-phosphate dehydrogenase I; GAPDH I 
Gene Name
 Gapdh1 
Gene Synonyms/Alias
 Gadph-1; CG12055 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
3*****MSKIGINGFGacetylation[1]
191TVDGPSGKLWRDGRGacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702
Functional Description
  
Sequence Annotation
 NP_BIND 11 12 NAD (By similarity).
 REGION 148 150 Glyceraldehyde 3-phosphate binding (By
 REGION 208 209 Glyceraldehyde 3-phosphate binding (By
 ACT_SITE 149 149 Nucleophile (By similarity).
 BINDING 32 32 NAD (By similarity).
 BINDING 77 77 NAD; via carbonyl oxygen (By similarity).
 BINDING 179 179 Glyceraldehyde 3-phosphate (By
 BINDING 231 231 Glyceraldehyde 3-phosphate (By
 BINDING 313 313 NAD (By similarity).  
Keyword
 Complete proteome; Cytoplasm; Glycolysis; NAD; Oxidoreductase; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 332 AA 
Protein Sequence
MSKIGINGFG RIGRLVLRAA IDKGASVVAV NDPFIDVNYM VYLFKFDSTH GRFKGTVAAE 60
GGFLVVNGQK ITVFSERDPA NINWASAGAE YVVESTGVFT TIDKASTHLK GGAKKVIISA 120
PSADAPMFVC GVNLDAYSPD MKVVSNASCT TNCLAPLAKV INDNFEIVEG LMTTVHATTA 180
TQKTVDGPSG KLWRDGRGAA QNIIPAATGA AKAVGKVIPA LNGKLTGMAF RVPTPNVSVV 240
DLTVRLGKGA TYDEIKAKVE EASKGPLKGI LGYTDEEVVS TDFFSDTHSS VFDAKAGISL 300
NDKFVKLISW YDNEFGYSNR VIDLIKYMQS KD 332 
Gene Ontology
 GO:0005811; C:lipid particle; IDA:FlyBase.
 GO:0031430; C:M band; IDA:FlyBase.
 GO:0030018; C:Z disc; IDA:FlyBase.
 GO:0004365; F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity; IDA:FlyBase.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0050661; F:NADP binding; IEA:InterPro.
 GO:0006096; P:glycolysis; IEP:FlyBase. 
Interpro
 IPR020831; GlycerAld/Erythrose_P_DH.
 IPR020830; GlycerAld_3-P_DH_AS.
 IPR020829; GlycerAld_3-P_DH_cat.
 IPR020828; GlycerAld_3-P_DH_NAD(P)-bd.
 IPR006424; Glyceraldehyde-3-P_DH_1.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF02800; Gp_dh_C
 PF00044; Gp_dh_N 
SMART
 SM00846; Gp_dh_N 
PROSITE
 PS00071; GAPDH 
PRINTS
 PR00078; G3PDHDRGNASE.