CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017174
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 UDP-glucuronosyltransferase 3A2 
Protein Synonyms/Alias
 UDPGT 3A2 
Gene Name
 Ugt3a2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
70IPDFRKEKPSYQVINubiquitination[1]
86RPPEDQEKKFADLRHacetylation[2]
127CSQLLSRKDIMDFLKubiquitination[1]
404NMVRVEAKNLGVSIQubiquitination[1]
441KSAAMASKIIRHSHPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
 UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity). 
Sequence Annotation
 CARBOHYD 52 52 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Glycoprotein; Glycosyltransferase; Membrane; Reference proteome; Signal; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 523 AA 
Protein Sequence
MAAHRRWLLM SFLFLEVILL EAAKILTIST LSASHYIVIS RVSQVLHEGG HNVTKLLYES 60
ANIPDFRKEK PSYQVINWRP PEDQEKKFAD LRHRLTEEIT YGRSKHHTLL KIHQYFGDLC 120
SQLLSRKDIM DFLKNENFDL VLLDSMDLCS LLIVEKLGKR FVSFLPFQFS YMDFGLPSAP 180
LSYAPVYGSG LTDQMDFWGR VKNFLMFLDF SMKQREILSQ YDSTIQEHFV EGSQPVLSDL 240
LLKAELWFVN SDFALDFARP LFPNTVYVGG LLDKPVQPIP QDLENFISQF GDSGFVLVAL 300
GSIVSMIQSK EIIKEMNSAF AHLPQGVLWT CKTSHWPKDV SLAPNVKIMD WLPQTDLLAH 360
PSIRLFVTHG GMNSVMEAVH HGVPMVGIPF FFDQPENMVR VEAKNLGVSI QLQTLKAESF 420
ALTMKKIIED KRYKSAAMAS KIIRHSHPLT PAQRLLGWID HILQTGGAAH LKPYAFQQPW 480
HEQYMLDVFL FLLGLMLGTL WLSVKVLVAV TRYLSIATKV KEA 523 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0015020; F:glucuronosyltransferase activity; IEA:EC.
 GO:0008194; F:UDP-glycosyltransferase activity; IDA:MGI.
 GO:0071412; P:cellular response to genistein; ISO:MGI. 
Interpro
 IPR002213; UDP_glucos_trans. 
Pfam
 PF00201; UDPGT 
SMART
  
PROSITE
 PS00375; UDPGT 
PRINTS