| Tag | Content |
|---|
| CPLM ID | CPLM-019672 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Regulator of microtubule dynamics protein 3 |
Protein Synonyms/Alias | RMD-3; hRMD-3; Cerebral protein 10; Protein FAM82A2; Protein FAM82C; Protein tyrosine phosphatase-interacting protein 51; TCPTP-interacting protein 51 |
Gene Name | RMDN3 |
Gene Synonyms/Alias | FAM82A2; FAM82C; PTPIP51; hucep-10; UNQ3122/PRO10274 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 206 | EVSCETVKMGRKDSL | ubiquitination | [1] | | 210 | ETVKMGRKDSLDLEE | ubiquitination | [1] | | 305 | KSYALDGKEEAEAAL | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. |
Sequence Annotation | MOD_RES 44 44 Phosphoserine.
MOD_RES 46 46 Phosphoserine.
MOD_RES 50 50 Phosphoserine (By similarity).
MOD_RES 189 189 Phosphoserine (By similarity).
MOD_RES 212 212 Phosphoserine. |
Keyword | Alternative splicing; Apoptosis; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Differentiation; Membrane; Microtubule; Mitochondrion; Mitochondrion outer membrane; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 470 AA |
Protein Sequence | MSRLGALGGA RAGLGLLLGT AAGLGFLCLL YSQRWKRTQR HGRSQSLPNS LDYTQTSDPG 60
RHVMLLRAVP GGAGDASVLP SLPREGQEKV LDRLDFVLTS LVALRREVEE LRSSLRGLAG 120
EIVGEVRCHM EENQRVARRR RFPFVRERSD STGSSSVYFT ASSGATFTDA ESEGGYTTAN 180
AESDNERDSD KESEDGEDEV SCETVKMGRK DSLDLEEEAA SGASSALEAG GSSGLEDVLP 240
LLQQADELHR GDEQGKREGF QLLLNNKLVY GSRQDFLWRL ARAYSDMCEL TEEVSEKKSY 300
ALDGKEEAEA ALEKGDESAD CHLWYAVLCG QLAEHESIQR RIQSGFSFKE HVDKAIALQP 360
ENPMAHFLLG RWCYQVSHLS WLEKKTATAL LESPLSATVE DALQSFLKAE ELQPGFSKAG 420
RVYISKCYRE LGKNSEARWW MKLALELPDV TKEDLAIQKD LEELEVILRD 470 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005874; C:microtubule; IEA:UniProtKB-KW. GO:0005741; C:mitochondrial outer membrane; IDA:UniProtKB. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. GO:0006874; P:cellular calcium ion homeostasis; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |