UniProt Accession

 GLRX1_YEAST; P25373; D6VQY0 

Genbank Protein ID

 X59720; BK006937 

Genbank Nucleotide ID

 CAA42381.1; DAA07449.1 

Protein Name

 Glutaredoxin-1 

Protein Synonyms/Alias

 Glutathione-dependent oxidoreductase 1 

Gene Name

 GRX1 

Gene Synonyms/Alias

 YCL035C; YCL35C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
11	QETIKHVKDLIAENE	acetylation	[1]
11	QETIKHVKDLIAENE	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 

Functional Description

 Multifunctional enzyme with glutathione-dependent oxidoreductase, glutathione peroxidase and glutathione S- transferase (GST) activity. The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing cytosolic protein- and non-protein-disulfides in a coupled system with glutathione reductase. Required for resistance to reactive oxygen species (ROS) by directly reducing hydroperoxides and for the detoxification of ROS-mediated damage. 

Sequence Annotation

 DOMAIN 7 110 Glutaredoxin.
 DISULFID 27 30 Redox-active (By similarity).  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Disulfide bond; Electron transport; Redox-active center; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 110 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0015036; F:disulfide oxidoreductase activity; ISS:SGD.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0004602; F:glutathione peroxidase activity; IDA:SGD.
 GO:0004364; F:glutathione transferase activity; IDA:SGD.
 GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0034599; P:cellular response to oxidative stress; IMP:SGD.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
 GO:0010731; P:protein glutathionylation; IGI:SGD. 

Interpro

 IPR011767; GLR_AS.
 IPR002109; Glutaredoxin.
 IPR011899; Glutaredoxin_euk/vir.
 IPR014025; Glutaredoxin_subgr.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00462; Glutaredoxin 

SMART

  

PROSITE

 PS00195; GLUTAREDOXIN_1
 PS51354; GLUTAREDOXIN_2 

PRINTS

 PR00160; GLUTAREDOXIN.