CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024243
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Anthranilate synthase component 1 
Protein Synonyms/Alias
 Anthranilate synthase component I 
Gene Name
 trpE 
Gene Synonyms/Alias
 MSMEG_3217; MSMEI_3135 
Created Date
 July 27, 2013 
Organism
 Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) 
NCBI Taxa ID
 246196 
Lysine Modification
Position
Peptide
Type
References
355EEDVLLEKELLADEKpupylation[1]
Reference
 [1] Expansion of the mycobacterial "PUPylome".
 Watrous J, Burns K, Liu WT, Patel A, Hook V, Bafna V, Barry CE 3rd, Bark S, Dorrestein PC.
 Mol Biosyst. 2010 Feb;6(2):376-85. [PMID: 20094657
Functional Description
  
Sequence Annotation
 CROSSLNK 355 355 Isoglutamyl lysine isopeptide (Lys-Gln)  
Keyword
 Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; Isopeptide bond; Lyase; Reference proteome; Tryptophan biosynthesis; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 524 AA 
Protein Sequence
MQTTANHSSR STQTGTRAHG AALAETTSRE DFRALATEHR VVPVIRKVLA DSETPLSAYR 60
KLAANRPGTF LLESAENGRS WSRWSFIGAG APSALTVRDN AAAWLGTAPE GAPSGGDPLD 120
ALRATLDLLK TEAMAGLPPL SSGLVGFFAY DMVRRLERLP ELAVDDLGLP DMLLLLATDI 180
AAVDHHEGTI TLIANAVNWN GTDERVDWAY DDAVARLDVM TKALGQPLTS AVATFSRPAP 240
DHRAQRTMEE YTEIVDKLVG DIEAGEAFQV VPSQRFEMDT AADPLDVYRI LRVTNPSPYM 300
YLLNIPDADG GLDFSIVGSS PEALVTVKDG RATTHPIAGT RWRGATEEED VLLEKELLAD 360
EKERAEHLML VDLGRNDLGR VCRPGTVRVD DYSHIERYSH VMHLVSTVTG ELAEDKTALD 420
AVTACFPAGT LSGAPKVRAM ELIEEVEKTR RGLYGGVVGY LDFAGNADFA IAIRTALMRN 480
GTAYVQAGGG VVADSNGPYE YTEAANKARA VLNAIAAAAT LAEP 524 
Gene Ontology
 GO:0004049; F:anthranilate synthase activity; IEA:EC.
 GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR005801; ADC_synthase.
 IPR019999; Anth_synth_I.
 IPR006805; Anth_synth_I_N.
 IPR005256; Anth_synth_I_PabB.
 IPR015890; Chorismate-bd_C. 
Pfam
 PF04715; Anth_synt_I_N
 PF00425; Chorismate_bind 
SMART
  
PROSITE
  
PRINTS
 PR00095; ANTSNTHASEI.