UniProt Accession

 GLRX2_ECOLI; P0AC59; P39811; P75928; P77043 

Genbank Protein ID

 X92076; U00096; AP009048 

Genbank Nucleotide ID

 CAA63058.1; AAC74148.1; BAA35872.1 

Protein Name

 Glutaredoxin-2 

Protein Synonyms/Alias

 Grx2 

Gene Name

 grxB 

Gene Synonyms/Alias

 b1064; JW1051 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
14	DHCPYCLKARMIFGL	acetylation	[1, 2]
46	PTRMVGQKQVPILQK	acetylation	[2]
53	KQVPILQKDDSRYMP	acetylation	[2]
71	DIVHYVDKLDGKPLL	acetylation	[2]
75	YVDKLDGKPLLTGKR	acetylation	[2]
81	GKPLLTGKRSPAIEE	acetylation	[2]
99	KVNGYANKLLLPRFA	acetylation	[2]
107	LLLPRFAKSAFDEFS	acetylation	[1, 2]
125	ARKYFVDKKEASAGN	acetylation	[1, 2]
126	RKYFVDKKEASAGNF	acetylation	[1, 2]
145	AHSDGLIKNISDDLR	acetylation	[1, 2]
156	DDLRALDKLIVKPNA	acetylation	[2]
203	DYRDNMAKQTQINLL	acetylation	[2]

Reference

 [1] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [2] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Involved in reducing some disulfide bonds in a coupled system with glutathione reductase. Does not act as hydrogen donor for ribonucleotide reductase. 

Sequence Annotation

 DOMAIN 1 77 GST N-terminal.
 DISULFID 9 12 Redox-active (By similarity).  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Disulfide bond; Electron transport; Redox-active center; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 215 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:EcoCyc.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0015038; F:glutathione disulfide oxidoreductase activity; IDA:EcoCyc.
 GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW. 

Interpro

 IPR011767; GLR_AS.
 IPR007494; Glutaredoxin2_C.
 IPR010987; Glutathione-S-Trfase_C-like.
 IPR004045; Glutathione_S-Trfase_N.
 IPR011901; GRXB.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF04399; Glutaredoxin2_C 

SMART

  

PROSITE

 PS00195; GLUTAREDOXIN_1
 PS50404; GST_NTER 

PRINTS