UniProt Accession

 E9Q242_MOUSE; E9Q242 

Genbank Protein ID

 AC125540; AC141880 

Genbank Nucleotide ID

  

Protein Name

 Adenylosuccinate lyase 

Protein Synonyms/Alias

  

Gene Name

 Adsl 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
132	SRLADFAKDRADLPT	acetylation	[1]
184	ELRFRGVKGTTGTQA	ubiquitination	[2]
203	LFEGDHQKVEQLDKM	ubiquitination	[2]
269	EMEEPFEKQQIGSSA	acetylation	[3]
280	GSSAMPYKRNPMRSE	acetylation	[1, 4]
400	QQAAAVVKQEGGDND	acetylation	[3]
455	EEVRPLLKPYGNEMA	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 469 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0004018; F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity; ISA:MGI.
 GO:0006167; P:AMP biosynthetic process; ISA:MGI. 

Interpro

 IPR019468; AdenyloSucc_lyase_C.
 IPR003031; D_crystallin.
 IPR024083; Fumarase/histidase_N.
 IPR000362; Fumarate_lyase.
 IPR020557; Fumarate_lyase_CS.
 IPR022761; Fumarate_lyase_N.
 IPR008948; L-Aspartase-like.
 IPR004769; Pur_lyase. 

Pfam

 PF10397; ADSL_C
 PF00206; Lyase_1 

SMART

 SM00998; ADSL_C 

PROSITE

 PS00163; FUMARATE_LYASES 

PRINTS

 PR00145; ARGSUCLYASE.
 PR00149; FUMRATELYASE.