UniProt Accession

 ARPC1_YEAST; P38328; D6VQN0 

Genbank Protein ID

 Z36103; AY692758; BK006936 

Genbank Nucleotide ID

 CAA85197.1; AAT92777.1; DAA07350.1 

Protein Name

 Actin-related protein 2/3 complex subunit 1 

Protein Synonyms/Alias

 Arp2/3 complex 41 kDa subunit; p41-ARC 

Gene Name

 ARC40 

Gene Synonyms/Alias

 YBR234C; YBR1532 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
19	VAVYKLVKAPIYSHC	ubiquitination	[1]
98	PLSDGTYKPTLVLLR	ubiquitination	[1]
121	TWAPNGYKFAVGSSA	methylation	[2]
185	RVFSGFIKGLDSKES	acetylation	[3]
190	FIKGLDSKESVAGSP	acetylation	[3]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Identification of arginine- and lysine-methylation in the proteome of Saccharomyces cerevisiae and its functional implications.
 Pang CN, Gasteiger E, Wilkins MR.
 BMC Genomics. 2010 Feb 5;11:92. [PMID: 20137074]
 [3] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). 

Sequence Annotation

 REPEAT 61 99 WD 1.
 REPEAT 105 146 WD 2.
 REPEAT 151 190 WD 3.
 REPEAT 212 251 WD 4.
 REPEAT 349 383 WD 5.  

Keyword

 Actin-binding; Complete proteome; Cytoplasm; Cytoskeleton; Reference proteome; Repeat; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 384 AA 

Protein Sequence

Gene Ontology

 GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.
 GO:0005885; C:Arp2/3 protein complex; IDA:SGD.
 GO:0043130; F:ubiquitin binding; IDA:SGD.
 GO:0045010; P:actin nucleation; IDA:SGD. 

Interpro

 IPR017383; ARPC2/3_su1.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS