CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013154
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Splicing factor, suppressor of white-apricot homolog 
Protein Synonyms/Alias
 Splicing factor, arginine/serine-rich 8; Suppressor of white apricot protein homolog 
Gene Name
 Sfswap 
Gene Synonyms/Alias
 Sfrs8; Srsf8; Swap 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
315SRLEELMKPLKVVDPacetylation[1, 2]
583ISFAIKAKENDLLPLacetylation[3]
929ITQDLMAKVRAMLAAacetylation[1, 2, 3]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
 Plays a role as an alternative splicing regulator. Regulates its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10 (By similarity). 
Sequence Annotation
 REPEAT 211 253 SURP motif 1.
 REPEAT 458 498 SURP motif 2.
 MOD_RES 283 283 Phosphoserine.
 MOD_RES 315 315 N6-acetyllysine (By similarity).
 MOD_RES 601 601 Phosphoserine.
 MOD_RES 639 639 Phosphothreonine.
 MOD_RES 903 903 Phosphoserine (By similarity).  
Keyword
 Acetylation; Coiled coil; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; RNA-binding; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 945 AA 
Protein Sequence
MYGAGGGRAK PERKGGVKEE AGPGGTGTGG NRVELLVFGY ACKLFRDDER ALAQEQGQHL 60
IPWMGDPKIL IDRYDGRGHL HDLSAYDAEY ATWNRDYQLS EEEARVEALC DEERYLALHT 120
DLLEEEARQE EEYKRLSEAL AEDGNYSAVG FTYGSDYYDP SEPTEEEEPS KQREKNEAEN 180
LEENEEPFIA PLGLSVPSDV ELPPTAKMHA IIERTANFVC KQGAQFEIML KAKQARNSQF 240
DFLRFDHYLN PYYKFIQKAM KEGRYTVLAE SKNEEKKKSG PTSDNEEEDD EEDGSYLHPS 300
LFASKKSSRL EELMKPLKVV DPDHPLAALV RKAQADSSAP APPTADGTPA QPSQVEYTAD 360
STVAAMYYSY YMLPDGTYCL APPPPGIDVA TYYSTLPAGV TVSSSPGVTT TVPPPPGTTP 420
PPPPTTAEPS SGVTSTTTTT SALAPVAIIP PPPDIQPVID KLAEYVARNG LKFETSVRAK 480
NDQRFEFLQP WHQYNAYYEF KKQFFLQKEG GGSTQAASTA EEAPTETAVE ESGEAGEDGA 540
PEGMAETGGR GSGKKEAGSS KSTVDGKLVK ASFAPISFAI KAKENDLLPL EKNRVKLDDD 600
SEEDEESREC QESTSSVANP SPAAAPPSVA VEEKKPQLTQ EELEAKQAKQ KLEDRLAAAA 660
REKLAQASKE SKEKQLQAER KRKAALFLQT LKNPLPEAEV GKLEESTFGV EDTGVMPCPL 720
LVGGRTLPIL EGKPPERPSN RCRDPPREEE REKKKKKHKK RSRTRSRSPK YHSSSKPRSR 780
SHSKAKHSLP SAYRTVRRSR SRSRSPRRRA HSPERRREER SVPTAYRMSG SPGVSRKRTR 840
SRSPHEKKKK RRSRSRTKAK ARSQSTSPSK QAAQRPSAHS AHSASISPVE SRGSSQERSR 900
GVSQEKDGQI SSAIVSSVQS KITQDLMAKV RAMLAASKNL QTSAS 945 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0048025; P:negative regulation of mRNA splicing, via spliceosome; ISS:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR000061; Surp.
 IPR019147; SWAP_N_domain. 
Pfam
 PF09750; DRY_EERY
 PF01805; Surp 
SMART
 SM00648; SWAP 
PROSITE
 PS50128; SURP 
PRINTS