UniProt Accession

 CBWD2_HUMAN; Q8IUF1; Q0VAN3 

Genbank Protein ID

 AF452722; AY343910; AK290072; AL078621; AC016745; BC120991; BC120992 

Genbank Nucleotide ID

 AAN64907.1; AAQ76868.1; BAF82761.1; CAO03555.1; CAO03555.1; AAI20992.1; AAI20993.1 

Protein Name

 COBW domain-containing protein 2 

Protein Synonyms/Alias

 Cobalamin synthase W domain-containing protein 2 

Gene Name

 CBWD2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
41	EKSGLGAKIPVTIIT	ubiquitination	[1, 2]
55	TGYLGAGKTTLLNYI	ubiquitination	[1]
69	ILTEQHSKRVAVILN	ubiquitination	[1, 2]
113	GCLCCSVKDNGLRAI	ubiquitination	[2]
126	AIENLMQKKGKFDYI	ubiquitination	[1]
127	IENLMQKKGKFDYIL	ubiquitination	[2]
176	VDSKYGLKHLAEEKP	ubiquitination	[1, 2, 3]
182	LKHLAEEKPDGLINE	ubiquitination	[2]
204	ADAILINKTDLVPEE	ubiquitination	[1, 2]
214	LVPEEDVKKLRATIR	ubiquitination	[1, 2]
215	VPEEDVKKLRATIRS	ubiquitination	[2]
258	LSGISLQKKLQHVPG	ubiquitination	[1]
306	WEKNVRNKDNHCMEV	ubiquitination	[2]
317	CMEVIRLKGLVSIKD	ubiquitination	[2]
323	LKGLVSIKDKSQQVI	ubiquitination	[2]
325	GLVSIKDKSQQVIVQ	ubiquitination	[1]
348	EETPVSWKDDTERTN	ubiquitination	[1, 2]
366	LLGRNLDKDILKQLF	ubiquitination	[2]
370	NLDKDILKQLFIATV	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

  

Sequence Annotation

 DOMAIN 274 377 CobW C-terminal.
 NP_BIND 49 56 ATP (Potential).
 NP_BIND 110 114 ATP (Potential).
 NP_BIND 203 206 ATP (Potential).  

Keyword

 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 395 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:UniProtKB-KW. 

Interpro

 IPR011629; Cbl_biosynth_CobW-like_C.
 IPR003495; CobW/HypB/UreG_dom.
 IPR027417; P-loop_NTPase. 

Pfam

 PF02492; cobW
 PF07683; CobW_C 

SMART

 SM00833; CobW_C 

PROSITE

  

PRINTS