CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018155
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Small glutamine-rich tetratricopeptide repeat-containing protein beta 
Protein Synonyms/Alias
 Beta-SGT 
Gene Name
 Sgtb 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
5***MSSVKPLVYAVIubiquitination[1]
131NRAAAQSKLSHYTDAubiquitination[1]
151KAIAIDSKYSKAYGRubiquitination[1]
178EAVTSYQKALDLDPEubiquitination[1]
190DPENDSYKSNLKIAEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity (By similarity). 
Sequence Annotation
 REPEAT 15 49 TPR 1.
 REPEAT 85 118 TPR 2.
 REPEAT 120 152 TPR 3.
 REPEAT 153 186 TPR 4.
 MOD_RES 295 295 Phosphoserine (By similarity).
 MOD_RES 297 297 Phosphoserine (By similarity).  
Keyword
 Chaperone; Complete proteome; Phosphoprotein; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 304 AA 
Protein Sequence
MSSVKPLVYA VIRFLREQSQ MDAYTSDEQE SLEVAIQCLE TVFKISPEDT HLAVSQPLTE 60
MFTNSVCKND IRPLSNSVPE DVGKADQLKD EGNNHMKEEN YAAAVDCYTQ AIELDPNNAV 120
YYCNRAAAQS KLSHYTDAIK DCEKAIAIDS KYSKAYGRMG LALTAMNKFE EAVTSYQKAL 180
DLDPENDSYK SNLKIAEQKL REVSSPTGTG LSFDMASLIN NPAFITMAAS LMQNPQVQQL 240
MSGMMTNAIG GPAAGVGGLT DLSSLIQAGQ QFAQQIQQQN PELIEQLRNH IRSRSFSSSA 300
DEHS 304 
Gene Ontology
 GO:0046982; F:protein heterodimerization activity; ISA:MGI.
 GO:0042803; F:protein homodimerization activity; ISA:MGI. 
Interpro
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
 PF00515; TPR_1 
SMART
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS