UniProt Accession

 ADCK4_HUMAN; Q96D53; Q8TAJ1; Q9HA52 

Genbank Protein ID

 BC013114; BC027473; AK022291 

Genbank Nucleotide ID

 AAH13114.2; AAH27473.1; BAB14004.1 

Protein Name

 Uncharacterized aarF domain-containing protein kinase 4 

Protein Synonyms/Alias

  

Gene Name

 ADCK4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
424	LQKSRDLKFLTGFET	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr). 

Sequence Annotation

 DOMAIN 191 423 Protein kinase.  

Keyword

 Alternative splicing; Complete proteome; Kinase; Membrane; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 544 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR004147; UbiB_dom. 

Pfam

 PF03109; ABC1 

SMART

  

PROSITE

 PS50011; PROTEIN_KINASE_DOM 

PRINTS