UniProt Accession

 THAP5_HUMAN; Q7Z6K1 

Genbank Protein ID

 CH236947; BC053634 

Genbank Nucleotide ID

 EAL24383.1; AAH53634.1 

Protein Name

 THAP domain-containing protein 5 

Protein Synonyms/Alias

  

Gene Name

 THAP5 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
103	SKKKSQKKNLEDEKE	ubiquitination	[1]
109	KKNLEDEKEVCPKAK	ubiquitination	[1]
331	YCRQDINKEHLWQKV	ubiquitination	[1]
351	KITLLELKEQQTLGR	ubiquitination	[1, 2, 3]
360	QQTLGRLKSLEALIR	ubiquitination	[1]
370	EALIRQLKQENWLSE	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 May be a regulator of cell cycle: THAP5 overexpression in human cell lines causes cell cycle arrest at G2/M phase. 

Sequence Annotation

 ZN_FING 1 84 THAP-type.
 MOTIF 321 324 HCFC1-binding motif (HBM) (By  

Keyword

 Alternative splicing; Cell cycle; Coiled coil; Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 395 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0045786; P:negative regulation of cell cycle; IMP:UniProtKB. 

Interpro

 IPR026518; THAP5_mammal.
 IPR006612; Znf_C2CH. 

Pfam

 PF05485; THAP 

SMART

 SM00692; DM3
 SM00980; THAP 

PROSITE

 PS50950; ZF_THAP 

PRINTS