CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013915
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Active breakpoint cluster region-related protein 
Protein Synonyms/Alias
  
Gene Name
 Abr 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
204KAFVDNYKVALETAEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 GTPase-activating protein for RAC and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them (By similarity). 
Sequence Annotation
 DOMAIN 91 284 DH.
 DOMAIN 301 459 PH.
 DOMAIN 491 595 C2.
 DOMAIN 647 845 Rho-GAP.  
Keyword
 Alternative splicing; Complete proteome; GTPase activation; Guanine-nucleotide releasing factor; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 859 AA 
Protein Sequence
MAAGGRRRRP LRYQSLAALV EDSQWPFLFL VSDFSYGAED YDAEGHEEQK GPPEGSETMP 60
YIDESPTMSP QLSARSQGGG DSVSPTPPEG LAPGVEAGKG LEMRKLVLSG FLASEEIYIN 120
QLEALLLPMK PLKATATTSQ PVLTIQQIET IFYKIQDIYE IHKEFYDNLC PKVQQWDSQV 180
TMGHLFQKLA SQLGVYKAFV DNYKVALETA EKCSQSNNQF QKISEELKVK GPKDSKDSHT 240
SVTMEALLYK PIDRVTRSTL VLHDLLKHTP VDHPDYPLLQ DALRISQNFL SSINEDIDPR 300
RTAVTTPKGE TRQLVKDGFL VEMSESSRKL RHVFLFTDVL LCAKLKKTSA GKHQQYDCKW 360
YIPLADLVFP SPEESEASPQ VHPFPDHELE DMKTKISALK SEIQKEKANK GQSRAIERLK 420
KKMFENEFLL LLNSPTIPFR IHNRNGKSYL FLLSSDYERS EWREAIQKLQ KKDLQAFVLS 480
SVELQVLTGS CFKLRTVHNI PVTSNKDDDE SPGLYGFLHV IVHSAKGFKQ SANLYCTLEV 540
DSFGYFVSKA KTRVFRDTTE PKWDEEFEIE LEGSQSLRIL CYEKCYDKTK VNKDNNEIVD 600
KIMGKGQIQL DPQTVESKNW HTDVIEMNGI KVEFSMKFTS RDMSLKRTPS KKQTGVFGVK 660
ISVVTKRERS KVPYIVRQCI EEVEKRGIEE VGIYRISGVA TDIQALKAVF DANNKDILLM 720
LSDMDINAIA GTLKLYFREL PEPLLTDRLY PAFMEGIALS DPAAKENCMM HLLRSLPDPN 780
LITFLFLLEH LKRVAEKEPI NKMSLHNLAT VFGPTLLRPS EVESKAHLTS AADIWSHDVM 840
AQVQVLLYYL QHPPISFAEL KRNTLYFSTD V 871 
Gene Ontology
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0005886; C:plasma membrane; IDA:MGI.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0030675; F:Rac GTPase activator activity; IDA:MGI.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0030036; P:actin cytoskeleton organization; IGI:MGI.
 GO:0007420; P:brain development; IGI:MGI.
 GO:0042472; P:inner ear morphogenesis; IGI:MGI.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0030336; P:negative regulation of cell migration; IGI:MGI.
 GO:0050728; P:negative regulation of inflammatory response; IMP:MGI.
 GO:0043314; P:negative regulation of neutrophil degranulation; IGI:MGI.
 GO:0050885; P:neuromuscular process controlling balance; IGI:MGI.
 GO:0050766; P:positive regulation of phagocytosis; IGI:MGI.
 GO:0032496; P:response to lipopolysaccharide; IMP:MGI. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR000219; DH-domain.
 IPR001331; GDS_CDC24_CS.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR008936; Rho_GTPase_activation_prot.
 IPR000198; RhoGAP_dom. 
Pfam
 PF00168; C2
 PF00169; PH
 PF00620; RhoGAP
 PF00621; RhoGEF 
SMART
 SM00239; C2
 SM00233; PH
 SM00324; RhoGAP
 SM00325; RhoGEF 
PROSITE
 PS50004; C2
 PS00741; DH_1
 PS50010; DH_2
 PS50003; PH_DOMAIN
 PS50238; RHOGAP 
PRINTS